The mutation p53N236S (p53S) has been identified as one of the recurrent mutations in
human cancers by TCGA database. Our in vitro data revealed the oncogenic gain of function …

p14 ARF, a product of the INK4A/ARF locus, induces p53 upregulation by neutralizing the
effects of MDM2, a transcriptional target of p53 that antagonizes its function. Here we report …

The ARF protein product of the ink4a/arf locus is induced by a variety of oncogenic signals.
ARF facilitates growth arrest through the p53 pathway by hindering the down-regulation of …

Alterations in the ARF tumour suppressor protein (also known as p14ARF in humans and
p19ARF in the mouse) occur frequently in cancer and are associated with susceptibility to …

The INK4a/ARF locus is regarded as one of the most important anti-tumoral defenses that
mammalian organisms possess. The characterization of its two gene products, p16INK4a …

The CDKN2 gene encodes two structurally different proteins: a cyclin‐dependent kinase
inhibitor called p16, which regulates retinoblastoma protein (pRb)‐dependent G1 arrest, and …

Cisplatin has been shown to induce apoptosis in various types of cancer cells. Despite the
great efficacy at treating certain kinds of cancers, cisplatin introduced into clinical use shows …

The locus encoding the tumor suppressor p16 has been found to code for a second, different
protein. This protein, p14ARF, has been shown to protect p53 from degradation. Like p16, its …

Abstract p14 ARF is a tumour suppressor which plays a critical role in p53-dependent or-
independent cell growth control. Several studies have recently provided evidence that p14 …

Abstract The INK4A/ARF tumor suppressor locus is frequently inactivated in hepatocellular
carcinoma (HCC), yet the consequences of this remain unknown. We recently described a …