Tumor suppressor protein p19 ARF (Arf; p14 ARF in humans) functions in both p53-
dependent and-independent modes to counteract hyper-proliferative signals caused by …

p19ARF has been implicated as a key regulator of p53 stability and activation. While
numerous stresses activate the p53 growth arrest pathway, those requiring p19ARF remain …

The p14 alternate reading frame (ARF) tumor suppressor plays a central role in cancer by
binding to mdm2 (Hdm2 in humans) and enhancing p53-mediated apoptosis following DNA …

The protein p14ARF is a known tumor suppressor protein controlling cell proliferation and
survival, which mainly localizes in nucleoli. However, the regulatory mechanisms that …

Abstract The unique INK4A/ARF locus at chromosome 9p21 encodes two distinct proteins
that intimately link the pRB and p53 tumour suppressor pathways. p16 INK4A has been …

Tumors without p53 mutation are often resistant to p53 gene therapy. We examined the
mechanism using p53-resistant A549 cells and p53-sensitive H1299 cells. We found that …

The INK4a locus on chromosome 9p21 encodes two structurally distinct tumor suppressor
proteins, p16 INK4a and the alternative reading frame protein, ARF (p19 ARF in mouse and …

Objective To investigate the synergistic antitumor effects of combined use of p14ARF gene
and 5-fluorouracil (5-Fu) in pancreatic cancer. Methods A human pancreatic cancer cell line …

ONYX-015 has been reported to kill selectively tumor cells lacking functional p53. Genetic
alterations of INK4a/ARF locus, which is a predominant event in malignant pleural …

In this study, in order to investigate the p53-independent function of p14ARF, we established
p14ARF-inducible clones in the p53-deficient HCT cell line using the doxycycline-inducible …