[HTML][HTML] p14ARF post-transcriptional regulation of nuclear cyclin D1 in MCF-7 breast cancer cells: discrimination between a good and bad prognosis?
As part of a cell's inherent protection against carcinogenesis, p14ARF is upregulated in
response to hyperproliferative signalling to induce cell cycle arrest. This property makes …
response to hyperproliferative signalling to induce cell cycle arrest. This property makes …
Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines
YB Park, MJ Park, K Kimura, K Shimizu, SH Lee… - Cancer genetics and …, 2002 - Elsevier
Two different proteins, p16INK4a and p14ARF, encoded by the INK4a/ARF locus play
important roles in the RB and p53 pathways, respectively. This study was performed to …
important roles in the RB and p53 pathways, respectively. This study was performed to …
[HTML][HTML] p14ARF interacts with the focal adhesion kinase and protects cells from anoikis
The ARF protein functions as an important sensor of hyper-proliferative stimuli restricting cell
proliferation through both p53-dependent and-independent pathways. Although to date the …
proliferation through both p53-dependent and-independent pathways. Although to date the …
A functional link between the tumour suppressors ARF and p33ING1
The ARF tumour suppressor protein plays a critical role in the activation of p53 in response
to oncogenic stress. ARF can activate p53 through nucleolar sequestration of Mdm2 …
to oncogenic stress. ARF can activate p53 through nucleolar sequestration of Mdm2 …
Loss of p14ARF expression in melanoma
R Dobrowolski, R Hein, R Buettner… - Archives of dermatological …, 2002 - Springer
Lack of p14 ARF expression or its functional inactivation has been observed in human and
murine carcinomas. Although very few mutations of p14 ARF have been detected in some …
murine carcinomas. Although very few mutations of p14 ARF have been detected in some …
Regulation of the p14ARF promoter by DNA methylation
V Badal, S Menendez, D Coomber, DP Lane - Cell Cycle, 2008 - Taylor & Francis
The INK4a/ARF locus encodes p14ARF which plays an important role in the p53 pathway.
Interestingly, methylation of the INK4a/ARF locus is a common event in carcinogenesis. In …
Interestingly, methylation of the INK4a/ARF locus is a common event in carcinogenesis. In …
The Pattern of p14ARF Expression in Primary and Metastatic Human Endometrial Carcinomas
P Olcha, M Cybulski, D Skomra, B Obrzut… - International Journal of …, 2010 - ijgc.bmj.com
Objectives: Alterations of p53 pathway (p14ARF/MDM2/p53) play a crucial role in the
development and progression of various human neoplasms, including endometrial …
development and progression of various human neoplasms, including endometrial …
Abnormalities of the ARF-p53 pathway in oral squamous cell carcinoma
G Bradley, J Irish, C MacMillan, K Mancer, I Witterick… - Oncogene, 2001 - nature.com
Oral squamous cell carcinoma (OSCC) is associated with heavy smoking and drinking, but
the molecular pathway of tumorigenesis is not understood. Inactivation of the p53 tumor …
the molecular pathway of tumorigenesis is not understood. Inactivation of the p53 tumor …
The ARF tumor suppressor can promote the progression of some tumors
O Humbey, J Pimkina, JT Zilfou, M Jarnik… - Cancer research, 2008 - AACR
Abstract p14/p19ARF (ARF) is a tumor suppressor gene that is frequently mutated in human
cancer. ARF has multiple tumor suppressor functions, some of which are mediated by …
cancer. ARF has multiple tumor suppressor functions, some of which are mediated by …
[HTML][HTML] p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes
E Roper, W Weinberg, FM Watt, H Land - EMBO reports, 2001 - embopress.org
In tumorigenesis of the skin, activated Ras co-operates with mutations that inactivate the
tumour suppressor p53, but the molecular basis for this co-operation remains unresolved …
tumour suppressor p53, but the molecular basis for this co-operation remains unresolved …