Epidemiological and experimental studies suggest a protective role of estrogens against
colorectal cancer. This effect seems to be mediated by their binding to estrogen receptor …

Estrogen is an important sex steroid hormone which serves an important role in the
regulation of a number of biological functions, including regulating bone density, brain …

Estrogen replacement therapy in postmenopausal women is associated with a reduction in
colorectal cancer risk, potentially via interactions between 17β-estradiol (E2) and the …

Epidemiological and experimental evidence suggests that estrogen replacement therapy
reduces the risk of colon cancer in postmenopausal women. Estrogen receptor beta (ERβ) is …

Obesity is associated with the increased incidence of colon cancer. Many cancer risk factors
have been identified including increased blood levels of insulin, leptin, interleukin-6 …

Several epidemiological, cellular, and molecular studies demonstrate the role of
environmental chemicals with endocrine disrupting activities, typical of Westernized …

Introduction Colorectal cancer is the third cause of death in industrialized countries. Genetic
susceptibility and diet are determinant of cancer risk and tumor behavior. Variation in cancer …

Estrogens act by binding to and activating two estrogen receptors (ERs), ERα and ERβ.
Transcriptional regulation by ERs is controlled by a complex array of factors such as ER …

Abstract Background and Aims Studies revealed that estrogenic signals were involved in the
development of colorectal cancer (CRC), while the roles of estrogen related receptor (ERR) …

By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ
exert opposite effects on cellular processes that include proliferation, apoptosis and …