Structure and function of aquaporin water channels

AS Verkman, AK Mitra - American Journal of Physiology …, 2000 - journals.physiology.org
The aquaporins (AQPs) are a family of small membrane-spanning proteins (monomer size∼
30 kDa) that are expressed at plasma membranes in many cells types involved in fluid …

Cellular and molecular biology of the aquaporin water channels

M Borgnia, S Nielsen, A Engel… - Annual review of …, 1999 - annualreviews.org
▪ Abstract The high water permeability characteristic of mammalian red cell membranes is
now known to be caused by the protein AQP1. This channel freely permits movement of …

Aquaporins: phylogeny, structure, and physiology of water channels

JB Heymann, A Engel - Physiology, 1999 - journals.physiology.org
How water permeates cellular membranes and what this means for cell functioning and
several diseases are now emerging from the study of the aquaporins (AQPs), the water …

Aquaporin water channels–from atomic structure to clinical medicine

P Agre, LS King, M Yasui, WB Guggino… - The Journal of …, 2002 - Wiley Online Library
The water permeability of biological membranes has been a longstanding problem in
physiology, but the proteins responsible for this remained unknown until discovery of the …

Molecular biology of aquaporins

C Li, W Wang - Aquaporins, 2017 - Springer
Aquaporins (AQPs) are a family of membrane water channels that basically function as
regulators of intracellular and intercellular water flow. To date, thirteen AQPs, which are …

Beyond water homeostasis: Diverse functional roles of mammalian aquaporins

P Kitchen, RE Day, MM Salman, MT Conner… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Background Aquaporin (AQP) water channels are best known as passive transporters of
water that are vital for water homeostasis. Scope of review AQP knockout studies in whole …

The evolutionary aspects of aquaporin family

K Ishibashi, S Kondo, S Hara… - American Journal of …, 2011 - journals.physiology.org
Aquaporins (AQPs) were originally identified as channels facilitating water transport across
the plasma membrane. They have a pair of highly conserved signature sequences …

Aquaporin water channels: unanswered questions and unresolved controversies

P Agre, D Brown, S Nielsen - Current opinion in cell biology, 1995 - Elsevier
The long-standing biophysical question of how water crosses plasma membranes has been
answered by the recent discovery of the aquaporins. Identification of this large family of …

From structure to disease: the evolving tale of aquaporin biology

LS King, D Kozono, P Agre - Nature reviews Molecular cell biology, 2004 - nature.com
Our understanding of the movement of water through cell membranes has been greatly
advanced by the discovery of a family of water-specific, membrane-channel proteins—the …

Aquaporins as targets for drug discovery

NA Castle - Drug discovery today, 2005 - Elsevier
Over the past decade, significant advances have been made in understanding how water
moves in to and out of cells. Investigators have used molecular and structural biological …