Structure and function of aquaporin water channels
AS Verkman, AK Mitra - American Journal of Physiology …, 2000 - journals.physiology.org
The aquaporins (AQPs) are a family of small membrane-spanning proteins (monomer size∼
30 kDa) that are expressed at plasma membranes in many cells types involved in fluid …
30 kDa) that are expressed at plasma membranes in many cells types involved in fluid …
Cellular and molecular biology of the aquaporin water channels
M Borgnia, S Nielsen, A Engel… - Annual review of …, 1999 - annualreviews.org
▪ Abstract The high water permeability characteristic of mammalian red cell membranes is
now known to be caused by the protein AQP1. This channel freely permits movement of …
now known to be caused by the protein AQP1. This channel freely permits movement of …
Aquaporins: phylogeny, structure, and physiology of water channels
JB Heymann, A Engel - Physiology, 1999 - journals.physiology.org
How water permeates cellular membranes and what this means for cell functioning and
several diseases are now emerging from the study of the aquaporins (AQPs), the water …
several diseases are now emerging from the study of the aquaporins (AQPs), the water …
Aquaporin water channels–from atomic structure to clinical medicine
P Agre, LS King, M Yasui, WB Guggino… - The Journal of …, 2002 - Wiley Online Library
The water permeability of biological membranes has been a longstanding problem in
physiology, but the proteins responsible for this remained unknown until discovery of the …
physiology, but the proteins responsible for this remained unknown until discovery of the …
Molecular biology of aquaporins
C Li, W Wang - Aquaporins, 2017 - Springer
Aquaporins (AQPs) are a family of membrane water channels that basically function as
regulators of intracellular and intercellular water flow. To date, thirteen AQPs, which are …
regulators of intracellular and intercellular water flow. To date, thirteen AQPs, which are …
Beyond water homeostasis: Diverse functional roles of mammalian aquaporins
Background Aquaporin (AQP) water channels are best known as passive transporters of
water that are vital for water homeostasis. Scope of review AQP knockout studies in whole …
water that are vital for water homeostasis. Scope of review AQP knockout studies in whole …
The evolutionary aspects of aquaporin family
K Ishibashi, S Kondo, S Hara… - American Journal of …, 2011 - journals.physiology.org
Aquaporins (AQPs) were originally identified as channels facilitating water transport across
the plasma membrane. They have a pair of highly conserved signature sequences …
the plasma membrane. They have a pair of highly conserved signature sequences …
Aquaporin water channels: unanswered questions and unresolved controversies
The long-standing biophysical question of how water crosses plasma membranes has been
answered by the recent discovery of the aquaporins. Identification of this large family of …
answered by the recent discovery of the aquaporins. Identification of this large family of …
From structure to disease: the evolving tale of aquaporin biology
Our understanding of the movement of water through cell membranes has been greatly
advanced by the discovery of a family of water-specific, membrane-channel proteins—the …
advanced by the discovery of a family of water-specific, membrane-channel proteins—the …
Aquaporins as targets for drug discovery
NA Castle - Drug discovery today, 2005 - Elsevier
Over the past decade, significant advances have been made in understanding how water
moves in to and out of cells. Investigators have used molecular and structural biological …
moves in to and out of cells. Investigators have used molecular and structural biological …