Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean
prompt achievement and maintenance of optimal exposure at the infection site with broad …

This article is a brief overview of empiric antibiotic selection for sepsis and septic shock. The
article includes a differential diagnosis of the mimics of sepsis and stresses a strategy for …

Patients with sepsis present across a spectrum of infection sites and severity of illnesses
requiring complex decision making at the bedside as to when prompt antibiotics are …

Sepsis is one of the oldest and most elusive syndromes in medicine. Every effort should be
made to treat these patients with the best available evidence. As a milestone, empiric …

Objectives: To assess the use of antibiotic de-escalation in patients with hospital-acquired
severe sepsis in an academic setting. Design: We reviewed all episodes of severe sepsis …

There has been little improvement in septic shock mortality in the past 70 years, despite ever
more broad-spectrum and potent antimicrobials. In the past, resuscitative elements have …

A fundamental step in the successful management of sepsis and septic shock is early
empiric antimicrobial therapy. However, for this to be effective, several decisions must be …

Sepsis is a medical emergency and life-threatening condition due to a dysregulated host
response to infection, which is time-dependent and associated with unacceptably high …

Objective To evaluate the impact of de-escalation therapy on clinical outcomes in patients
with severe sepsis and/or septic shock. Methods We performed a systematic literature …

International guidelines concerning the management of patients with sepsis, septic shock
and multiple organ failure make no reference to the nature of the infecting organism. Indeed …