Cyclin D1b is a splice variant of the cell cycle regulator cyclin D1 and is known to harbor
divergent and highly oncogenic functions in human cancer. While cyclin D1b is induced …

Prostate cancer (PCa) cell proliferation is dependent on activation of the androgen receptor
(AR), a ligand-dependent transcription factor. AR activation controls G1–S phase …

D-type cyclins regulate cellular outcomes in part through cyclin-dependent, kinase-
independent mechanisms that modify transcription factor action, and recent in vivo studies …

Cyclin D1 is a multifaceted regulator of both transcription and cell-cycle progression that
exists in two distinct isoforms, cyclin D1a and D1b. In the prostate, cyclin D1a acts through …

Regulation of the androgen receptor (AR) is critical to prostate cancer (PCa) development;
therefore, AR is the first line therapeutic target for disseminated tumors. Cell cycle …

Androgen receptor regulation is pivotal for prostate growth and development. Activation of
the receptor is dictated by association with androgen (ligand) and through interaction with co …

The function of cyclin D1 as a positive regulator of the cell cycle and proto-oncogene has
been well established. Cyclin D1 elicits its pro-proliferative function early in G1 phase …

BACKGROUND Slug is a transcription factor of the Snail/Slug zinc‐finger family and is
implicated in metastasis of tumors, but its role in cell proliferation of prostate cancers is …

Background Cyclin A1 is a cell cycle regulator that has been implicated in the progression of
prostate cancer. Its role in invasion and metastasis of this disease has not been …

The cyclin D1b oncogene arises from alternative splicing of the CCND1 transcript, and
harbors markedly enhanced oncogenic functions not shared by full-length cyclin D1 (cyclin …