Research evidence is necessary but insufficient for making patient care decisions. An
effective but toxic chemotherapeutic regimen is the treatment one patient with cancer can …

Background: Randomized controlled trials (RCTs) remain the accepted “gold standard” for
determining the efficacy of new drugs or medical procedures. Randomized trials alone …

To the Editor: Hofmann and colleagues (1) observed that in their experience" a majority of
seriously ill inpatients had not discussed and were not interested in discussing preferences …

Evidence-based medicine and clinical practice guidelines have become increasingly salient
to the international health care community in the 1990s. Key issues in health policy in this …

The Institute of Medicine (IOM) recently updated its standards for guideline development. 1 If
adhered to, trustworthy guidelines should follow. Trustworthiness connotes integrity …

Randomized, Controlled Trials in Health Insurance Systems | NEJM Skip to main content NEJM
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Background: Information retrieval for systematic reviews in occupational injuries and other
public health areas is much more elusive than retrieval for reviews in clinical medicine, due …

Background Rapid reviews have the potential to overcome a key barrier to the use of
research evidence in decision making, namely that of the lack of timely and relevant …

The consumer of health care services expects that medical practice is based on scientific
evidence with regard to efficacy and effectiveness. Randomized controlled trials provide the …

The systematic literature review, widely regarded as the gold standard for determining
evidencebased practice, is increasingly used to guide policy decisions and the direction of …