Early identification of infants with sickle cell disease (SCD) by newborn screening, now
universal in all 50 states in the US, has improved survival, mainly by preventing …

Sickle cell disease (SCD) is the name for a group of genetic blood disorders caused by
sickle hemoglobin (Hb S). The 2 key features of SCD are chronic hemolytic anemia and …

Once a fatal disease of childhood, more than 95% of patients born today with sickle cell
disease (SCD) in developed countries are expected to survive into adulthood, largely …

Proper management of sickle cell anemia (SCA) begins with establishing the correct
diagnosis early in life, ideally during the newborn period. The identification of affected …

Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation
in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in …

Introduction: The perception of an asymptomatic sickle cell disease (SCD) state is a
misnomer. Children without overt symptoms, likely have subclinical disease beginning in …

The first clinical description of sickle cell anemia was published in 1910 by Herri~ k?~ who
reported some of the clinical and hematologic manifestations of the disorder in a 20-year-old …

Sickle cell disease (SCD) is a complex, clinically heterogeneous disorder affecting
approximately 100,000 individuals in the United States and millions worldwide. The disease …

As more children are appropriately being diagnosed, the burden of sickle cell disease is
increasing greatly in Africa and in high-resource countries such as the United States and …

Sickle cell disease (SCD) is a life-threatening genetic disorder characterized by chronic
hemolytic anemia, vascular injury and multiorgan dysfunctions. Over the last few decades …