Several Plasmodium vivax relapses after correct primaquine treatment in a patient with impaired cytochrome P450 2D6 function
A Martin Ramírez, C Lombardia González… - Malaria Journal, 2020 - Springer
Background Plasmodium vivax malaria is characterized by the presence of dormant liver-
stage parasites, called hypnozoites, which can cause malaria relapses after an initial attack …
stage parasites, called hypnozoites, which can cause malaria relapses after an initial attack …
Increased primaquine total dose prevents Plasmodium vivax relapses in patients with impaired CYP2D6 activity: report of three cases
A de Pina-Costa, ACR Silvino, EM Dos Santos… - Malaria Journal, 2021 - Springer
Background The relapsing nature of Plasmodium vivax infection is a major barrier to its
control and elimination. Factors such as adequate dosing, adherence, drug quality, and …
control and elimination. Factors such as adequate dosing, adherence, drug quality, and …
[HTML][HTML] Four times of relapse of Plasmodium vivax malaria despite primaquine treatment in a patient with impaired cytochrome P450 2D6 function
S Choi, H Choi, SY Park, YG Kwak… - The Korean journal of …, 2022 - ncbi.nlm.nih.gov
Plasmodium vivax exhibits dormant liver-stage parasites, called hypnozoites, which can
cause relapse of malaria. The only drug currently used for eliminating hypnozoites is …
cause relapse of malaria. The only drug currently used for eliminating hypnozoites is …
Multiple relapses of Plasmodium vivax malaria acquired from West Africa and association with poor metabolizer CYP2D6 variant: a case report
X He, M Pan, W Zeng, C Zou, L Pi, Y Qin, L Zhao… - BMC Infectious …, 2019 - Springer
Background Plasmodium vivax transmission in West Africa, dominant for the Duffy-negative
blood group, has been increasingly recognized from both local residents as well as …
blood group, has been increasingly recognized from both local residents as well as …
Association between CYP2D6 phenotype and recurrence of Plasmodium vivax infection in south Korean patients
S Choi, H Choi, SY Park, YG Kwak, JE Song, SY Shin… - Malaria Journal, 2022 - Springer
Background Primaquine is activated by CYP2D6 in the hepatocytes. In Korea, primaquine is
the only hypnozoitocidal agent used for patients with vivax malaria. Thus, patients with poor …
the only hypnozoitocidal agent used for patients with vivax malaria. Thus, patients with poor …
Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study
Background Plasmodium vivax malaria is characterized by relapses arising from the
hypnozoite stages in the liver. The only currently registered drug for radical treatment to …
hypnozoite stages in the liver. The only currently registered drug for radical treatment to …
CYP2D6 activity and the risk of recurrence of Plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study
LW Brasil, F Rodrigues-Soares, AB Santoro… - Malaria journal, 2018 - Springer
Background CYP2D6 pathway mediates the activation of primaquine into active metabolite
(s) in hepatocytes. CYP2D6 is highly polymorphic, encoding CYP2D6 isoforms with normal …
(s) in hepatocytes. CYP2D6 is highly polymorphic, encoding CYP2D6 isoforms with normal …
The clinical and public health problem of relapse despite primaquine therapy: case review of repeated relapses of Plasmodium vivax acquired in Papua New Guinea
RJH Ingram, C Crenna-Darusallam, S Soebianto… - Malaria journal, 2014 - Springer
Background Primaquine is the only drug available for preventing relapse following a primary
attack by Plasmodium vivax malaria. This drug imposes several important problems: daily …
attack by Plasmodium vivax malaria. This drug imposes several important problems: daily …
Cytochrome P450 2D6 profiles and their relationship with outcomes of primaquine anti-relapse therapy in Australian Defence Force personnel deployed to Papua …
N Chen, S Dowd, ML Gatton, A Auliff, MD Edstein… - Malaria Journal, 2019 - Springer
Background Primaquine, an 8-aminoquinoline with anti-hypnozoite activity against
Plasmodium vivax, is metabolized by human cytochrome P450 2D6 (CYP2D6) to its active …
Plasmodium vivax, is metabolized by human cytochrome P450 2D6 (CYP2D6) to its active …
Primaquine ineligibility in anti-relapse therapy of Plasmodium vivax malaria: the problem of G6PD deficiency and cytochrome P-450 2D6 polymorphisms
JK Baird, KE Battle, RE Howes - Malaria journal, 2018 - Springer
The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and
opportunity for ultimately eradicating this species. It is silent and cannot be diagnosed until it …
opportunity for ultimately eradicating this species. It is silent and cannot be diagnosed until it …