Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats

MH Ling, MC Chen - Acta biomaterialia, 2013 - Elsevier
This study presents a dissolving microneedle patch, composed of starch and gelatin, for the
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …

Dissolving microneedle patches for transdermal insulin delivery in diabetic mice: potential for clinical applications

CH Chen, VBH Shyu, CT Chen - Materials, 2018 - mdpi.com
In this study, dissolving polymeric microneedle (MN) patches composed of gelatin and
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …

Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin

W Yu, G Jiang, Y Zhang, D Liu, B Xu, J Zhou - Materials Science and …, 2017 - Elsevier
To reduce the inconvenient and painful of subcutaneous needle injection, the polymer
microneedle patches that fabricated from modified alginate and hyaluronate were prepared …

Transdermal Delivery of Insulin Using Microneedles in Vivo

W Martanto, SP Davis, NR Holiday, J Wang… - Pharmaceutical …, 2004 - Springer
Purpose. The purpose of this study was to design and fabricate arrays of solid microneedles
and insert them into the skin of diabetic hairless rats for transdermal delivery of insulin to …

Formulation of two‐layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice

IC Lee, WM Lin, JC Shu, SW Tsai… - … research Part A, 2017 - Wiley Online Library
Dissolving microneedles (MNs) display high efficiency in delivering poorly permeable drugs
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …

Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery

S Lau, J Fei, H Liu, W Chen, R Liu - Journal of Controlled Release, 2017 - Elsevier
Dissolving microneedles have been employed as a safe and convenient transdermal
delivery system for drugs and vaccines. To improve effective drug delivery, a multilayered …

Dissolving polymer microneedles for transdermal delivery of insulin

N Zhang, X Zhou, L Liu, L Zhao, H Xie… - Frontiers in …, 2021 - frontiersin.org
It's of great significance to develop insulin-loaded dissolving microneedles (MNs) which are
fabricated with various methods and materials for transdermal delivery of insulin to …

3D printed microneedles for insulin skin delivery

CPP Pere, SN Economidou, G Lall, C Ziraud… - International journal of …, 2018 - Elsevier
In this study, polymeric microneedle patches were fabricated by stereolithography, a 3D
printing technique, for the transdermal delivery of insulin. A biocompatible resin was …

Study on the fabrication and characterization of tip-loaded dissolving microneedles for transdermal drug delivery

J Zhuang, F Rao, D Wu, Y Huang, H Xu, W Gao… - European Journal of …, 2020 - Elsevier
In order to increase the utilization rate of drug carried by microneedles and reduce waste, a
two-step casting method was proposed to fabricate tip-loaded dissolving microneedles in …

Fabrication of biodegradable composite microneedles based on calcium sulfate and gelatin for transdermal delivery of insulin

W Yu, G Jiang, D Liu, L Li, H Chen, Y Liu… - Materials Science and …, 2017 - Elsevier
To reduce the inconvenience and pain of subcutaneous needle injection, the calcium sulfate
and gelatin biodegradable composite microneedle patches with high aspect-ratio …