Is the way to fight cancer paved with gold? Metal-based carbene complexes with multiple and fascinating biological features

D Iacopetta, C Rosano, M Sirignano, A Mariconda… - Pharmaceuticals, 2020 - mdpi.com
Herein, we report the synthesis and the multiple anti-tumor properties of new gold and silver
carbene complexes. The chemical modifications, grounded on our previous studies, led us …

A gold(i) biscarbene complex with improved activity as a TrxR inhibitor and cytotoxic drug: comparative studies with different gold metallodrugs

C Schmidt, L Albrecht, S Balasupramaniam… - Metallomics, 2019 - academic.oup.com
Gold complexes with N-heterocyclic carbene (NHC) ligands have been attracting major
attention in medicinal inorganic chemistry based on their favorable antiproliferative effects …

Chemistry and biology of two novel gold (I) carbene complexes as prospective anticancer agents

L Messori, L Marchetti, L Massai, F Scaletti… - Inorganic …, 2014 - ACS Publications
Two novel gold carbene compounds, namely, chlorido (1-butyl-3-methyl-imidazole-2-
ylidene) gold (I)(1) and bis (1-butyl-3-methyl-imidazole-2-ylidene) gold (I)(2), were prepared …

N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression

C Saturnino, I Barone, D Iacopetta… - Future Medicinal …, 2016 - Taylor & Francis
Aim: Metal carbenic complexes have received considerable attention in both the catalysis
and biological fields for their potential applications in cancer and antimicrobial therapies …

N-Heterocyclic carbene-gold (I) complexes targeting actin polymerization

D Iacopetta, J Ceramella, C Rosano, A Mariconda… - Applied Sciences, 2021 - mdpi.com
Transition metal complexes are attracting attention because of their various chemical and
biological properties. In particular, the NHC-gold complexes represent a productive field of …

Novel Au carbene complexes as promising multi-target agents in breast cancer treatment

J Ceramella, A Mariconda, M Sirignano, D Iacopetta… - Pharmaceuticals, 2022 - mdpi.com
Over the past decade, metal complexes based on N-heterocyclic carbenes (NHCs) have
attracted great attention due to their wide and exciting applications in material sciences and …

Anticancer Gold N‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study

N Estrada‐Ortiz, F Guarra, IAM de Graaf… - …, 2017 - Wiley Online Library
A series of organometallic AuI N‐heterocyclic carbene (NHC) complexes was synthesized
and characterized for anticancer activity in four human cancer cell lines. The compounds' …

A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds

B Bertrand, A Casini - Dalton Transactions, 2014 - pubs.rsc.org
From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold
has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an …

Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene–gold(i) complex

P Holenya, S Can, R Rubbiani, H Alborzinia… - Metallomics, 2014 - academic.oup.com
Due to their broad spectrum of biological activity and antiproliferative effect on different
human cancer cell lines, gold compounds have been in the focus of drug research for many …

Novel gold and silver carbene complexes exert antitumor effects triggering the reactive oxygen species dependent intrinsic apoptotic pathway

D Iacopetta, A Mariconda, C Saturnino… - …, 2017 - Wiley Online Library
Cisplatin and other platinum‐based drugs are well‐known valid anticancer drugs. However,
during chemotherapy, the presence of numerous side effects and the onset of frequent …