Developmental regulation of G protein‐gated inwardly‐rectifying K+ (GIRK/Kir3) channel subunits in the brain

L Fernández‐Alacid, M Watanabe… - European Journal of …, 2011 - Wiley Online Library
G protein‐gated inwardly‐rectifying K+ (GIRK/family 3 of inwardly‐rectifying K+) channels
are coupled to neurotransmitter action and can play important roles in modulating neuronal …

Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3

TM Jelacic, ME Kennedy, K Wickman… - Journal of Biological …, 2000 - ASBMB
G-protein-gated inwardly rectifying K+(GIRK) channels are widely expressed in the brain
and are activated by at least eight different neurotransmitters. As K+ channels, they drive the …

Cell type‐specific subunit composition of G protein‐gated potassium channels in the cerebellum

C Aguado, J Colón, F Ciruela… - Journal of …, 2008 - Wiley Online Library
G protein‐gated inwardly rectifying potassium (GIRK/Kir3) channels regulate cellular
excitability and neurotransmission. In this study, we used biochemical and morphological …

GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior

E Marron Fernandez de Velasco, L Zhang, B N. Vo… - Scientific reports, 2017 - nature.com
Many neurotransmitters directly inhibit neurons by activating G protein-gated inwardly
rectifying K+ (GIRK) channels, thereby moderating the influence of excitatory input on …

A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels

A Spauschus, KU Lentes, E Wischmeyer… - Journal of …, 1996 - Soc Neuroscience
Transcripts of a gene, GIRK4, that encodes for a 419-amino-acid protein and shows high
structural similarity to other subfamily members of G-protein-activated inwardly rectifying K+ …

Localization and targeting of GIRK channels in mammalian central neurons

R Luján, C Aguado - International review of neurobiology, 2015 - Elsevier
G protein-gated inwardly rectifying K+(GIRK/K ir 3) channels are critical to brain function.
They hyperpolarize neurons in response to activation of different G protein-coupled …

Structural elements in the Girk1 subunit that potentiate G protein–gated potassium channel activity

N Wydeven, D Young, K Mirkovic… - Proceedings of the …, 2012 - National Acad Sciences
G protein–gated inwardly rectifying K+ (Girk/KIR3) channels mediate the inhibitory effect of
many neurotransmitters on excitable cells. Girk channels are tetramers consisting of various …

G-protein-gated inward rectifier K+ channel proteins (GIRK1) are present in the soma and dendrites as well as in nerve terminals of specific neurons in the brain

A Ponce, E Bueno, C Kentros… - Journal of …, 1996 - Soc Neuroscience
G-protein-gated inward rectifier potassium (GIRK) channels are coupled to numerous
neurotransmitter receptors in the brain and can play important roles in modulating neuronal …

Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain

LS Del Burgo, R Cortes, G Mengod… - Journal of …, 2008 - Wiley Online Library
G‐protein inwardly rectifying potassium (GIRK) channels mediate the synaptic actions of
numerous neurotransmitters in the mammalian brain and play an important role in the …

Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4

K Wickman, C Karschin, A Karschin… - Journal of …, 2000 - Soc Neuroscience
Neuronal G-protein-gated potassium (KG) channels are activated by several
neurotransmitters and constitute an important mode of synaptic inhibition in the mammalian …