Approximately one-third of adolescents and adults in developed countries regularly
experience insufficient sleep across the school and/or work week interspersed with …

Behavioral studies indicate that the ability to acquire long-term memories is severely
impaired during sleep. It is unclear, however, why the highly synchronous discharge of …

Abstract Study Objectives: Prolonged wakefulness leads to a progressive increase in sleep
pressure, reflected in a global increase in slow wave activity (SWA, 0.5-4.5 Hz) in the sleep …

The brain-derived neurotrophic factor (BDNF) is associated with emotional and cognitive
functioning, and it is considered a transdiagnostic biomarker for mental disorders. Literature …

Many theories propose that sleep serves a purpose in synaptic plasticity. We tested the
hypothesis, therefore, that manipulation of sleep would affect the expression of molecules …

Neocortical pyramidal neurons respond to prolonged activity blockade by modulating their
balance of inward and outward currents to become more sensitive to synaptic input, possibly …

At its most basic level, the function of mammalian sleep can be described as a restorative
process of the brain and body; recently, however, progressive research has revealed a host …

Sleep enhances plasticity in neocortex, and thereby improves sensory learning. Here we
show that sleep itself undergoes changes as a consequence of waking experience during a …

Experience-dependent plasticity, the ability of the brain to constantly adapt to an ever-
changing environment, has been suggested to be highest during childhood and to decline …

The need to sleep grows with the duration of wakefulness and dissipates with time spent
asleep, a process called sleep homeostasis. What are the consequences of staying awake …