The Warburg effect is prevalent in human cancer. Accordingly, most cancer cells display
highly elevated glycolysis without proportionally increasing pyruvate oxidation. The …

The hypoxia-inducible factor-1α (HIF-1α), a key player in the adaptive regulation of energy
metabolism, and the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), a critical …

Background: Cancer is not just one disease; it is a group of diseases either genetic or
metabolic due to the malfunction of mitochondria. Thus, metabolic pathways are …

The Warburg effect-a classical hallmark of cancer metabolism-is a counter-intuitive
phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production …

Cancers are complex diseases having several unique features, commonly described as
'hallmarks of cancer'. Among them, altered signaling pathways are the common …

Metabolic reprogramming and altered bioenergetics have emerged as hallmarks of cancer
and an area of active basic and translational cancer research. Drastically upregulated …

The early landmark discoveries in cancer metabolism research have uncovered metabolic
processes that support rapid proliferation, such as aerobic glycolysis (Warburg effect) …

Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …

The Warburg effect (WE), or aerobic glycolysis, is commonly recognized as a hallmark of
cancer and has been extensively studied for potential anti-cancer therapeutics development …

Drug development groups are close to discovering another pot of gold-a therapeutic target-
similar to the success of imatinib (Gleevec) in the field of cancer biology. Modern molecular …