Simple Summary Lactic acidosis is a prominent feature of the tumour microenvironment and
a key player in cancer metabolism. This review is aimed at combining the mechanisms …

Although Warburg's discovery of intensive glucose uptake by tumors, followed by lactate
fermentation in oxygen presence of oxygen was made a century ago, it is still an area of …

Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Aerobic glycolysis, or the Warburg effect, is regarded as a critical part of metabolic
reprogramming and plays a crucial role in the occurrence and development of tumours …

In the 1920s, the biochemist Otto Warburg observed that, unlike normal cells, cancer cells
catabolize glucose into lactate under aerobic conditions (hence the name “The Warburg …

Introduction Adaptations of eukaryotic cells to environmental changes are important for their
survival. However, under some circumstances, microenvironmental changes promote that …

Abstract In 1927, Otto Warburg and coworkers reported the increased uptake of glucose and
production of lactate by tumors in vivo as compared with normal tissues. This phenomenon …

Glucose is a crucial molecule in energy production and produces different end products in
non-tumourigenic-and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose …

Cancer cells are characterized by altered glucose metabolism known as the Warburg effect
in which aerobic glycolysis is increased. Glucose is converted to lactate even under …

In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative
phosphorylation to generate the energy needed for cellular processes, most cancer cells …