Sound detection by inner ear hair cells requires tip links that interconnect mechanosensory
stereocilia and convey force to yet unidentified transduction channels. Current models …

Tip links are extracellular filaments that connect pairs of hair cell stereocilia and convey
tension to mechanosensitive channels. Recent evidence suggests that tip links are formed …

Mechanosensation is a primitive and somewhat ubiquitous sense. At the inner ear, sensory
hair cells are refined to enhance sensitivity, dynamic range and frequency selectivity. Thirty …

Background Sensorineural hearing loss is the most common sensory deficit in the world,
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …

Inner ear hair cells assemble mechanosensitive hair bundles on their apical surface that
transduce sounds and accelerations. Each hair bundle is comprised of∼ 100 individual …

Hair cells of the mammalian inner ear are the mechanoreceptors that convert sound-induced
vibrations into electrical signals. The molecular mechanisms that regulate the development …

Hair cells are mechanosensors for the perception of sound, acceleration, and fluid motion.
Mechanotransduction channels in hair cells are gated by tip links, which connect the …

Inner ear mechanosensory hair cells convert mechanical vibrations into electrical signals via
the coordinated interaction of multiple proteins precisely positioned within the sensory hair …

Human hearing relies upon the tip-to-tip interaction of two nonclassical cadherins,
protocadherin-15 (PCDH15) and cadherin-23 (CDH23). Together, these proteins form a …

Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are
gated by the tension of'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip …