Antibiotic treatment of tuberculosis has a duration of several months. There is significant
variability of the host immune response and the pharmacokinetic-pharmacodynamic …

Evaluating therapy efficacy is crucial for patients with tuberculosis (TB), especially those with
drug-resistant tuberculosis (DR-TB). The World Health Organization currently recommends …

New drugs, vaccines, and other therapies will be required to realise the goal of global
tuberculosis elimination or control. This Review covers the important role biomarkers can …

Untreated active tuberculosis (TB) has a very high long-term mortality. Treatment of TB
reduces mortality dramatically and should maximize cure, preventing ongoing transmission …

Although what actually constitutes tuberculosis might seem obvious—disease arising from
infection by members of the Mycobacterium tuberculosis complex(primarily but not …

Antibiotic treatment of tuberculosis takes≥ 6 months, putting a major burden on patients and
health systems in large parts of the world. Treatment beyond 2 months is needed to prevent …

Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a
global public health threat. A significant challenge for TB control efforts has been the …

Global initiatives have been launched to develop improved tuberculosis chemotherapy. New
drugs and potential treatment-shortening regimens require careful assessment in clinical …

Current WHO recommendations for monitoring treatment response in adult pulmonary
tuberculosis (TB) are sputum smear microscopy and/or culture conversion at the end of the …

Background Despite recent increased clinical trials activity, no regimen has proved able to
replace the standard 6-month regimen for drug-sensitive tuberculosis. Understanding the …