[HTML][HTML] Immune gene signature delineates a subclass of papillary thyroid cancer with unfavorable clinical outcomes

K Kim, S Jeon, TM Kim, CK Jung - Cancers, 2018 - mdpi.com
Papillary thyroid carcinoma (PTC) represents a heterogeneous disease with diverse clinical
outcomes highlighting a need to identify robust biomarkers with clinical relevance. We …

Characterization of immune landscape in papillary thyroid cancer reveals distinct tumor immunogenicity and implications for immunotherapy

J Sun, R Shi, X Zhang, D Fang, J Rauch, S Lu… - …, 2021 - Taylor & Francis
Although the vast majority of patients with papillary thyroid cancer (PTC) have a favorable
prognosis when conventional treatments are implemented, local recurrence and distant …

[HTML][HTML] Papillary Thyroid Carcinoma Variants are Characterized by Co-dysregulation of Immune and Cancer Associated Genes

J Chakladar, WT Li, M Bouvet, EY Chang… - Cancers, 2019 - mdpi.com
Papillary thyroid carcinoma (PTC) variants exhibit different prognosis, but critical
characteristics of PTC variants that contribute to differences in pathogenesis are not well …

[HTML][HTML] Immune landscape of papillary thyroid cancer and immunotherapeutic implications

KJ Na, H Choi - Endocrine-related cancer, 2018 - erc.bioscientifica.com
Although papillary thyroid cancer (PTC) is curable with excellent survival rate, patients with
dedifferentiated PTC suffer the recurrence or death. As cancer immune escape plays a …

[HTML][HTML] Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability

S Hong, Y Xie, Z Cheng, J Li, W He, Z Guo, Q Zhang… - Oncogene, 2022 - nature.com
Papillary thyroid carcinoma (PTC) is heterogeneous and its molecular characteristics remain
elusive. We integrated transcriptomic sequencing, genomic analysis and clinicopathologic …

Development and validation of a three-immune-related gene signature prognostic risk model in papillary thyroid carcinoma

X Gan, M Guo, Z Chen, Y Li, F Shen, J Feng… - Journal of …, 2021 - Springer
Purpose Increasing evidence indicates that there is a correlation between papillary thyroid
carcinoma (PTC) prognosis and the immune signature. Our goal was to construct a new …

[HTML][HTML] Development of a prognostic index based on an immunogenomic landscape analysis of papillary thyroid cancer

P Lin, Y Guo, L Shi, X Li, H Yang, Y He, Q Li… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Background: Papillary thyroid cancer (PTC) is the most common subtype of thyroid cancer,
and inflammation relates significantly to its initiation and prognosis. Systematic exploration …

Tumor immune microenvironment characteristics of papillary thyroid carcinoma are associated with histopathological aggressiveness and BRAF mutation status

C Means, DR Clayburgh, L Maloney, D Sauer… - Head & …, 2019 - Wiley Online Library
Background Papillary thyroid carcinoma (PTC) follows an indolent course; however, up to
30% of patients develop recurrent disease requiring further treatment. Profiling PTC immune …

[HTML][HTML] Integrated genomic characterization of papillary thyroid carcinoma

N Agrawal, R Akbani, BA Aksoy, A Ally, H Arachchi… - Cell, 2014 - cell.com
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

[HTML][HTML] Single-cell transcriptome analysis reveals inter-tumor heterogeneity in bilateral papillary thyroid carcinoma

T Wang, J Shi, L Li, X Zhou, H Zhang, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Background The tumor microenvironment (TME) plays a pivotal role in cancer progression in
papillary thyroid carcinoma (PTC), yet the composition and the phenotype of cells within the …