The brainstem plays a crucial role in sleep-wake regulation. However, the ensemble
dynamics underlying sleep regulation remain poorly understood. Here, we show slow, state …

Background Emerging data suggest an important relationship between sleep and
Alzheimer's disease (AD), but how poor sleep promotes the development of AD remains …

Although sleep is defined as a behavioral state, at the cortical level sleep has local and use-
dependent features suggesting that it is a property of neuronal assemblies requiring sleep in …

Astrocytes are the chief supportive cells in the central nervous system, but work over the past
20 years have documented that astrocytes also contribute to complex neural processes …

Background Astrocytes can mediate neurovascular coupling, modulate neuronal excitability,
and promote synaptic maturation and remodeling. All these functions are likely to be …

Slow wave activity (SWA) is a characteristic brain oscillation in sleep and quiet wakefulness.
Although the cell types contributing to SWA genesis are not yet identified, the principal role …

Extraordinary strides have been made toward understanding the complexities and
regulatory mechanisms of sleep over the past two decades thanks to the help of rapidly …

Low-threshold (T-type) Ca2+ channels encoded by the CaV3 genes endow neurons with
oscillatory properties that underlie slow waves characteristic of the non-rapid eye movement …

Wakefulness is driven by the widespread release of neuromodulators by the ascending
arousal system. Yet, it is unclear how these substances orchestrate state-dependent, global …

Microglia are important for brain homeostasis and immunity, but their role in regulating
vigilance remains unclear. We employed genetic, physiological, and metabolomic methods …