P2 purinergic receptors on osteoblasts and osteoclasts: potential targets for drug development
SJ Dixon, SM Sims - Drug Development Research, 2000 - Wiley Online Library
Extracellular nucleotides like ATP bind to cell surface receptors (P2 purinergic receptors) in
many tissues. P2X receptor subtypes are intrinsic ion channels that mediate depolarization …
many tissues. P2X receptor subtypes are intrinsic ion channels that mediate depolarization …
Purinergic signalling and bone remodelling
Accumulating evidence suggests that extracellular nucleotides, signalling through P2
receptors, could play an important role in modulating bone cell function. ATP and other …
receptors, could play an important role in modulating bone cell function. ATP and other …
[PDF][PDF] Purinergic signalling in osteoblasts
[Frontiers in Bioscience 17, 16-29, January 1, 2012] 16 Purinergic signalling in osteoblasts
Alison Gartland1, Isabel R Orriss2 Page 1 [Frontiers in Bioscience 17, 16-29, January 1, 2012] …
Alison Gartland1, Isabel R Orriss2 Page 1 [Frontiers in Bioscience 17, 16-29, January 1, 2012] …
[PDF][PDF] Expression and function of P2 receptors in bone
JA Gallagher, KA Buckley - JOURNAL OF MUSCULOSKELETAL …, 2002 - researchgate.net
Abstract ATP (adenosine 5'-triphosphate) is one of the most important extracellular
regulatory molecules in the skeleton. Extracellular ATP and other nucleotides signal through …
regulatory molecules in the skeleton. Extracellular ATP and other nucleotides signal through …
P2 Receptors in Bone—Modulation of Osteoclast Formation and Activity via P2X7 Activation
A Gartland, KA Buckley, RA Hipskind… - Critical Reviews™ in …, 2003 - dl.begellhouse.com
The concept that adenosine triphosphate (ATP) can act as an extracellular signaling
molecule via interactions with specific purinergic receptors to mediate a wide variety of …
molecule via interactions with specific purinergic receptors to mediate a wide variety of …
[HTML][HTML] Purinergic signalling in bone
RMH Rumney, N Wang, A Agrawal… - Frontiers in …, 2012 - frontiersin.org
Purinergic signaling in bone was first proposed in the early 1990s with the observation that
extracellular ATP could modulate events crucial to the normal functioning of bone cells …
extracellular ATP could modulate events crucial to the normal functioning of bone cells …
[HTML][HTML] The P2X7 receptor is an important regulator of extracellular ATP levels
A Brandao-Burch, ML Key, JJ Patel, TR Arnett… - Frontiers in …, 2012 - frontiersin.org
Controlled ATP release has been demonstrated from many neuronal and non-neuronal cell
types. Once released, extracellular ATP acts on cells in a paracrine manner via purinergic …
types. Once released, extracellular ATP acts on cells in a paracrine manner via purinergic …
Purinergic signalling in the musculoskeletal system
It is now widely recognised that extracellular nucleotides, signalling via purinergic receptors,
participate in numerous biological processes in most tissues. It has become evident that …
participate in numerous biological processes in most tissues. It has become evident that …
Regulation of bone resorption and formation by purines and pyrimidines
A Hoebertz, TR Arnett, G Burnstock - Trends in Pharmacological Sciences, 2003 - cell.com
Growing evidence suggests that extracellular nucleotides, signalling through P2 receptors,
might play important roles in the regulation of bone and cartilage metabolism. ATP and other …
might play important roles in the regulation of bone and cartilage metabolism. ATP and other …
[PDF][PDF] ATP P2 receptors and regulation of bone effector cells
JA Gallagher - JOURNAL OF MUSCULOSKELETAL AND …, 2004 - ismni.org
ATP, signaling through P2 receptors, is one of the most important extracellular regulatory
molecules in the skeleton. P2 receptors are divided into two subclasses, P2Y which are G …
molecules in the skeleton. P2 receptors are divided into two subclasses, P2Y which are G …