Although calcific aortic stenosis is a very common disease with major adverse
cardiovascular events and healthcare costs, there are no effective medical interventions to …

Calcific aortic stenosis is the most common indication for surgical valve replacement in the
United States. For years this disease has been described as a passive degenerative …

Calcific aortic valve disease (CAVD) is the most common valvular heart disease in
developed countries predominantly affecting the elderly population therefore posing a large …

Despite numerous promising therapeutic targets, there are no proven medical treatments for
calcific aortic stenosis (AS). Multiple stakeholders need to come together and several …

ACE has been identified in aortic sclerotic lesions. 13 Although there is evidence that some
ACE may be produced locally, the majority was extracellular and colocalized with …

Perrotta I, Russo E, Camastra C, Filice G, Di Mizio G, Colosimo F, Ricci P, Tripepi S, Amorosi
A, Triumbari F & Donato G (2011) Histopathology59, 504–513 New evidence for a critical …

Once thought to result from passive precipitation of calcium and phosphate, it now appears
that vascular calcification is a consequence of tightly regulated processes that culminate in …

Aortic valvular interstitial cells (VICs) isolated from patients undergoing valve replacement
are commonly used as in vitro models of calcific aortic valve disease (CAVD) …

Background—Over the past 10 to 15 years, calcific aortic valve disease, which includes
aortic sclerosis and aortic stenosis, has come to be recognized as an active process, based …

Although aortic stenosis is a common condition associated with major morbidity, mortality,
and health economic costs, there are currently no medical interventions capable of delaying …