Conformation capture technologies (eg, Hi-C) chart physical interactions between chromatin
regions on a genome-wide scale. However, the structural variability of the genome between …

Chromosome conformation capture technologies such as Hi-C are widely used to
investigate the spatial organization of genomes. Because genome structures can vary …

Several general principles of global 3D genome organization have recently been
established, including non-random positioning of chromosomes and genes in the cell …

Knowledge of spatial chromosomal organizations is critical for the study of transcriptional
regulation and other nuclear processes in the cell. Recently, chromosome conformation …

The highly dynamic nature of chromosome conformation and three-dimensional (3D)
genome organization leads to cell-to-cell variability in chromatin interactions within a cell …

Extracting biologically meaningful information from chromosomal interactions obtained with
genome-wide chromosome conformation capture (3C) analyses requires the elimination of …

How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

Genomes are spatiotemporally organized within the cell nucleus. Genome-wide
chromosome conformation capture (Hi-C) technologies have uncovered the 3D genome …

Chromosome conformation capture-based methods such as Hi-C have become mainstream
techniques for the study of the 3D organization of genomes. These methods convert …

The rapidly increasing quantity of genome-wide chromosome conformation capture data
presents great opportunities and challenges in the computational modeling and …