Background Amiodarone (AMD) and its metabolite N-desethylamiodarone can cause some
adverse effects, which include pulmonary toxicity. Some studies suggest that mitochondrial …

The role played by oxidative stress in amiodarone-induced mitochondrial toxicity is debated.
Dronedarone shows pharmacological properties similar to those of amiodarone but several …

Free Radicals and Amiodarone Toxicity. Introduction: In vitro and in vivo studies were
performed to elucidate the pathogenesis of amiodarone toxicity. Methods and Results: Rats …

Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce
severe pulmonary adverse effects, including fibrosis. Although the pathogenesis of AM …

Although, the antiarrhythmic effect of amiodarone (AMD) is well characterized, the
mechanism of its toxicity on extracardiac tissues is still poorly understood. Several …

Background: The clinical usefulness of amiodarone for the treatment of cardiac arrhythmias
is limited by multiorgan toxicity, especially pulmonary and hepatic. There are conflicting …

Amiodarone (AM) is an effective antidysrhythmic agent, restricted in use by the development
of adverse effects, including potentially fatal AM‐induced pulmonary toxicity (AIPT). Although …

Amiodarone is a widely used and potent antiarrhythmic agent that is metabolized to
desethylamiodarone. Both amiodarone and its metabolite possess antiarrhythmic effect, and …

Amiodarone‐(AM‐) induced pulmonary toxicity (AIPT) is still a matter of research and is
poorly understood. In attempting to resolve this issue, we treated Sprague‐Dawley rats with …

Although, the antiarrhythmic effect of amiodarone is well characterized, its effect on post-
ischemic heart and cardiomyocytes, as well as the mechanism of its toxicity on extracardiac …