We have studied whether curcumin prevents amiodarone‐induced lung fibrosis in rats.
Intratracheal instillation of amiodarone (6.25 mg kg− 1 on days 0 and 2, and then killed on …

Mitochondrial disorder is characteristic of many myocardial injuries such as endotoxemia,
shock, acidosis, ischemia/reperfusion, and others. The goal of possible therapy is to …

Mitochondrial dysfunction is a salient feature of myocardial ischemia/reperfusion injury
(MIRI), while the potential mechanism of mitochondrial dynamics disorder remains unclear …

The effectiveness of amiodarone in the treatment of cardiac arrhythmias is limited due to the
development of pulmonary toxicity. Although the biochemical and morphologic …

Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …

Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to …

To investigate whether amiodarone induces apoptosis in cells of the L-132 human lung
epithelial cell line, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay …

Introduction When confronted to stress or pathological conditions, the mitochondria
overproduce reactive species that participate in the cellular dysfunction. These organelles …

Context: The serious side effect of Adriamycin (ADR) is cardiomyopathy. Cryptotanshinone
(CRY) is widely and safely used as antioxidant with MTD more than 5 mg/g in rats (po) …

Astragaloside is one of the most common traditional Chinese medicines and is derived from
Astragalus membranaceus. Astragaloside IV (AsIV) is a monomer located in an extract of …