Neovascularization plays an important role in many physiological and pathological
processes, but its mechanism is still unclear. Since vascular cells are subjected to a variety …

Recent advances in medicine and healthcare allow people to live longer, increasing the
need for the number of organ transplants. However, the number of organ donors has not …

The mechanical and biochemical microenvironment influences the morphological
characteristics of microvascular networks (MVNs) formed by endothelial cells (ECs) …

The failure of synthetic vascular grafts due to de-endothelialization of the lumen as a result
of exposure to fluid-induced shear stress prevents the widespread use of such grafts as …

Vasculature is an essential component of physiologically relevant tissue, yet mimicking the
native vasculature is an ongoing challenge in tissue engineering. Microfabrication may …

The formation of a stably perfused microvasculature continues to be a major challenge in
tissue engineering. Previous work has suggested the importance of a sufficiently large …

Microengineering advances have enabled the development of perfusable, endothelialized
models of the microvasculature that recapitulate the unique biological and biophysical …

METHODS 1.5 mm Pluronic macrofibers were bridged by 100-500 μm Pluronic or 10-400
μm melt-spun Shellac microfibers. Networks were sacrificed within collagen and seeded …

Microfluidic technologies have enabled in vitro studies to closely simulate the in vivo
microvessel environment with sufficient complexity. However, the lack of functional …

Methods A multi-hairpin channel geometry with a diameter of 1.5 mm was designed in
SolidWorks and created using a 3D-printer. Flow parameters were calculated using fluid …