Nonalcoholic fatty liver disease (NAFLD) spectrum disorders affect approximately 1 billion
individuals worldwide. However, the drivers of progressive steatohepatitis remain …

Objective Aberrant ketogenesis is correlated with the degree of steatosis in non-alcoholic
fatty liver disease (NAFLD) patients, and an inborn error of ketogenesis (mitochondrial HMG …

While several molecular targets are under consideration, mechanistic underpinnings of the
transition from uncomplicated nonalcoholic fatty liver disease (NAFLD) to nonalcoholic …

Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …

Hepatic ketogenesis provides a vital systemic fuel during fasting because ketone bodies are
oxidized by most peripheral tissues and, unlike glucose, can be synthesized from fatty acids …

Nonalcoholic steatohepatitis (NASH) is a key step in the progression of nonalcoholic fatty
liver (NAFL) to cirrhosis. However, the molecular mechanisms of the NAFL-to-NASH …

Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease,
characterized by hepatic fat accumulation and possible development of inflammation …

BACKGROUND Hepatic de novo lipogenesis (DNL) and β-oxidation are tightly coordinated,
and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver …

Background & Aims The etiology of nonalcoholic fatty liver disease (NAFLD) is poorly
understood, with males and certain populations exhibiting markedly increased susceptibility …

Background & Aims The consumption of sugar and a high-fat diet (HFD) promotes the
development of obesity and metabolic dysfunction. Despite their well-known synergy, the …