Hyaluronic acid molecular weight determines lung clearance and biodistribution after instillation

C Kuehl, T Zhang, LM Kaminskas… - Molecular …, 2016 - ACS Publications
Hyaluronic acid (HA) has emerged as a versatile polymer for drug delivery. Multiple
commercial products utilize HA, it can be obtained in a variety of molecular weights, and it …

[HTML][HTML] Efficacy and safety of hyaluronate membrane in the rabbit cecum-abdominal wall adhesion model

JY Kim, WJ Cho, JH Kim, SH Lim… - Journal of the …, 2013 - synapse.koreamed.org
Purpose Tissue adhesion is a well-known postsurgical phenomenon, causing pain,
functional obstruction, and difficult reoperative surgery. To overcome these problems …

Hyaluronan in respiratory injury and repair

GM Turino, JO Cantor - American journal of respiratory and critical …, 2003 - atsjournals.org
Over the past two decades, much of the research on the cellular hyaluronic acid as the
terminology. HA is a naturally occurring, and biochemical reactions to injurious agents of the …

The graft content of hyaluronan is increased during xenograft rejection

T Lorant, G Tufveson, C Johnsson - Xenotransplantation, 2004 - Wiley Online Library
Background: Hyaluronan, a macromolecule with strong water binding capacity, is associated
with interstitial oedema during rejection of allogeneic transplants. However, the involvement …

Hyaluronate does not prevent adhesions

PK Amid - Archives of Surgery, 2002 - jamanetwork.com
1. Amid PK, Shulmann AG, Lichtenstein IL, Sostrin S, Young J, Hakakha M. Experimental
evaluation of a new composite mesh with the selective property of incorporation to the …

Accumulation of hyaluronan (hyaluronic acid) in myocardial interstitial tissue parallels development of transplantation edema in heart allografts in rats.

R Hällgren, B Gerdin, A Tengblad… - The Journal of clinical …, 1990 - Am Soc Clin Investig
By using biotin-labeled proteoglycan core protein, hyaluronan (hyaluronic acid; HA) was
visualized in rat heart grafts at different times (2, 4, and 6 d) after transplantation. In normal …

Effects of low-viscosity sodium hyaluronate preparation on the pulmonary absorption of rh-insulin in rats

K Morimoto, K Metsugi, H Katsumata… - Drug development …, 2001 - Taylor & Francis
Purpose: A low-viscosity formulation for pulmonary delivery of rh-insulin as model peptide
drugs was developed using a solution of sodium hyaluronate. Method: The effects of …

Lung hyaluronan as assayed with a biotinylated hyaluronan-binding protein

BA Bray, W Hsu, GM Turino - Experimental lung research, 1994 - Taylor & Francis
This study was designed to define how hyaluronan (HA) is bound in lung tissue. Aliquots of
lyophilized hamster lungs were extracted with 0.5 M NaCl (associative conditions) or 4 M …

Mechanism of impaired local hyaluronan turnover in bleomycin-induced lung injury in rat

P Teder, P Heldin - American journal of respiratory cell and …, 1997 - atsjournals.org
Hyaluronan, a linear polysaccharide, is accumulated in lung interstitium during different
pathological conditions, causing interstitial edema and thereby impaired lung function. We …

Decreased lung hyaluronan in a model of ARDS in the rat: effect of an inhibitor of leukocyte elastase

CM Ahn, H Sandler, T Saldeen - Upsala Journal of Medical …, 2012 - Taylor & Francis
Background. Hyaluronan (HA) is a component of the extracellular matrix in lung tissue and is
normally present at low concentrations in blood. HA is rapidly cleared from blood by the …