Aims/hypothesis Chronic inflammation in type 2 diabetes is proposed to affect islets as well
as insulin target organs. However, the nature of islet inflammation and its effects on islet …

The nature of obesity-associated islet inflammation and its impact on β cell abnormalities
remains poorly defined. Here, we explore immune cell components of islet inflammation and …

Activation of the innate immune system in obesity is a risk factor for the development of type
2 diabetes. The aim of the current study was to investigate the notion that increased …

Onset of Type 2 diabetes occurs when the pancreatic β-cell fails to adapt to the increased
insulin demand caused by insulin resistance. Morphological and therapeutic intervention …

Islets of patients with type 2 diabetes display the typical features of an inflammatory process
characterized by the presence of cytokines, chemokines, immune cell infiltration, impaired …

Considerable efforts have been invested to understand the mechanisms by which pro-
inflammatory cytokines mediate the demise of β-cells in type 1 diabetes but much less …

Type 1 diabetes mellitus (T1DM) is caused by the selective deletion of pancreatic β‐cells in
response to an assault mounted within the pancreas by infiltrating immune cells. However …

Recent studies suggest an inflammatory process, characterized by local cytokine/chemokine
production and immune cell infiltration, regulates islet dysfunction and insulin resistance in …

Macrophages are highly heterogeneous and plastic immune cells with peculiar
characteristics dependent on their origin and microenvironment. Following pathogen …

The role of the immune system is to restore functionality in response to stress. Increasing
evidence shows that this function is not limited to insults by infection or injury and plays a …