Inflammation and type one diabetes
Type one diabetes (T1D) is a complex T cell-mediated autoimmune disease, the defining
feature of which is the destruction of the insulin-secreting beta-(β)-cell. Both genetic and …
feature of which is the destruction of the insulin-secreting beta-(β)-cell. Both genetic and …
[HTML][HTML] Persistent or transient human β cell dysfunction induced by metabolic stress: specific signatures and shared gene expression with type 2 diabetes
Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we
assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate …
assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate …
[HTML][HTML] Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
S Demine, AA Schiavo, S Marín-Cañas… - Stem cell research & …, 2020 - Springer
Background Adult human pancreatic beta cells are the “gold standard” for studies on
diabetes pathogenesis, but their use is limited by insufficient availability and variable quality …
diabetes pathogenesis, but their use is limited by insufficient availability and variable quality …
[HTML][HTML] Interleukin-33-activated islet-resident innate lymphoid cells promote insulin secretion through myeloid cell retinoic acid production
E Dalmas, FM Lehmann, E Dror, S Wueest, C Thienel… - Immunity, 2017 - cell.com
Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during
obesity and type 2 diabetes. However, little is known about the nature and function of …
obesity and type 2 diabetes. However, little is known about the nature and function of …
Alterations in β-cell calcium dynamics and efficacy outweigh islet mass adaptation in compensation of insulin resistance and prediabetes onset
C Chen, H Chmelova, CM Cohrs, JA Chouinard… - Diabetes, 2016 - Am Diabetes Assoc
Emerging insulin resistance is normally compensated by increased insulin production of
pancreatic β-cells, thereby maintaining normoglycemia. However, it is unclear whether this …
pancreatic β-cells, thereby maintaining normoglycemia. However, it is unclear whether this …
[PDF][PDF] The implication of proinflammatory cytokines in type 2 diabetes
The incidence of type 2 diabetes (T2D) is rapidly expanding. Some of the more obvious
pathologies associated with it include: defective glucose metabolism, obesity …
pathologies associated with it include: defective glucose metabolism, obesity …
Diabetes mellitus and inflammation
E Lontchi-Yimagou, E Sobngwi, TE Matsha… - Current diabetes …, 2013 - Springer
Type 2 diabetes mellitus (T2DM) is increasingly common worldwide. Related complications
account for increased morbidity and mortality, and enormous healthcare spending …
account for increased morbidity and mortality, and enormous healthcare spending …