Conspectus The major advances in molecular and structural biology and automated peptide
and DNA synthesis of the 1970s and 1980s generated fertile conditions in the 1990s for the …

Protein design is a useful strategy to interrogate the protein structure‐function relationship.
We demonstrate using a highly modular 3‐stranded coiled coil (TRI‐peptide system) that a …

Enzymatic reactions involving redox processes are highly sensitive to the local electrostatic
environment. Despite considerable effort, the complex interactions among different …

Conspectus The relationship between structure and function has long been one of the major
points of investigation in Biophysics. Understanding how much, or how little, of a protein's …

Designed metal ion binding peptides offer a variety of applications in both basic science as
model systems of more complex metalloproteins, and in biotechnology, eg in bioremediation …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

De novo metallopeptide design contributes significantly to the understanding of protein
folding, protein–protein interactions, and metal-ion sites in biology.[1, 2] Within this rubric …

Over the past two decades, designed metallopeptides have held the promise for
understanding a variety of fundamental questions in metallobiochemistry; however, these …

Metalloenzymes efficiently catalyze some of the most important and difficult reactions in
nature. For many years, coordination chemists have effectively used small molecule models …

Advances in protein chemistry and molecular and structural biology have empowered
modern chemists to build complex biological architectures using a “first principles” …