Cardiac remodeling, which typically results from chronic hypertension or following an acute
myocardial infarction, is a major risk factor for the development of heart failure and …

ANG-(1–7) improves the function of the remodeling heart. Although this peptide is generated
directly within the myocardium, the effects of ANG-(1–7) on cardiac fibroblasts that play a …

Angiotensin-converting enzyme 2 (ACE2) converts the vasopressor angiotensin II (Ang II)
into angiotensin (1-7)[Ang (1-7)], a peptide reported to have vasodilatory and …

The objectives of the present study were to investigate the effect of ANG-(1–7) on the
development of cardiac hypertrophy and to identify the intracellular mechanism underlying …

Background—Accumulating evidence suggests that angiotensin-(1-7)(Ang-[1-7]) may play
an important role in counteracting the pressor, proliferative, and profibrotic actions of …

The systemic and regional hemodynamics effects of ANG-(1–7) were examined in urethane-
anesthetized rats. The blood flow distribution (kidneys, skin, mesentery, lungs, spleen, brain …

Background—The renin-angiotensin system (RAS) is a key player in the progression of
heart failure. Angiotensin-(1–7) is thought to modulate the activity of the RAS. Furthermore …

Angiotensin II (ANG II) contributes to hypertension, cardiac hypertrophy, fibrosis, and
dysfunction; however, it is difficult to separate the cardiac effect of ANG II from its …

Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

While the circulating renin-angiotensin system (RAS) plays an important role in short-term
maintenance of cardiovascular homeostasis, recent studies point to a role in long-term …