Connexins and pannexins are two families of large-pore channel forming proteins that are
capable of passing small signaling molecules. While connexins serve the seminal task of …

Pannexins have been proposed to play a role in gap junctional intercellular communication
and as single-membrane channels, although many of their molecular characteristics differ …

Although human pannexins (PanX) are homologous to gap junction molecules, their
physiological function in vertebrates remains poorly understood. Our results demonstrate …

Gap junctions (GJs) are composed of proteins that form a channel connecting the cytoplasm
of adjacent cells. Connexins were initially considered to be the only proteins capable of GJ …

Direct cell-to-cell communication through specialized intercellular channels is a
characteristic feature of virtually all multi-cellular organisms. The remarkable functional …

Connexins had been considered to be the only class of the vertebrate proteins capable of
gap junction formation; however, new candidates for this function with no homology to …

Pannexin2 (Panx2) is the largest of three members of the pannexin proteins. Pannexins are
topologically related to connexins and innexins, but serve different functional roles than …

Pannexins are homologous to innexins, the invertebrate gap junction family. However,
mammalian pannexin1 does not form canonical gap junctions, instead forming hexameric …

Pannexins are newly discovered channel proteins expressed in many different tissues and
abundantly in the vertebrate central nervous system. Based on membrane topology, folding …

The occurrence of intercellular channels formed by pannexin1 has been challenged for
more than a decade. Here, we provide an electrophysiological characterization of …