A number of observational studies have found that treated hypertensive patients, even those
with controlled clinic blood pressure (BP), might have poorer prognosis than untreated …

Several previous studies found that too great a reduction of clinic blood pressure (BP) by
treatment increased cardiovascular disease (CVD) risk, whereas moderate reduction …

Generally, hypertensive patients ingest all their blood pressure (BP)-lowering agents in the
morning. However, many published prospective trials have reported clinically meaningful …

In resistant hypertension, ingesting one or more blood pressure (BP)-lowering medications
at bedtime is associated with significant reduction of sleep-time BP, a sensitive prognostic …

Patients with resistant hypertension (RH) are at greater risk for stroke, renal insufficiency,
and cardiovascular disease (CVD) events than are those for whom blood pressure (BP) is …

Many published prospective trials have reported clinically meaningful morning-evening,
treatment-time differences in the blood pressure (BP)-lowering efficacy, duration of action …

Clinical studies have documented morning-evening, administration-time differences of
several different classes of hypertension medications in blood pressure (BP)-lowering …

Correlation between blood pressure (BP) and target organ damage, vascular risk and long-
term patient prognosis is greater for measurements derived from around-the-clock …

Introduction Office blood pressure measurements (OBPM), still used today for diagnosis and
management of hypertension, fail to reveal clinically important features of the mostly …

Abstract Aims The Hygia Chronotherapy Trial, conducted within the clinical primary care
setting, was designed to test whether bedtime in comparison to usual upon awakening …