GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer

S Han, C Cao, R Liu, YF Yuan, L Pan, M Xu, C Hu… - Cellular Oncology, 2022 - Springer
Purpose GAS41 is a YEATS domain protein that binds to acetylated histone H3 to promote
the chromatin deposition of H2A. Z in non-small cell lung cancer. The role of GAS41 in …

Gas7 attenuates hepatocellular carcinoma progression and chemoresistance through the PI3K/Akt signaling pathway

WF Liu, QW Zhang, B Quan, F Zhang, M Li, SX Lu… - Cellular …, 2023 - Elsevier
Growth arrest-specific gene 7 (Gas7) was involved in various cellular functions, although its
specific roles and molecular mechanisms in hepatocellular carcinoma (HCC) remained …

Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6

X Lu, Y Fang, Z Wang, J Xie, Q Zhan, X Deng… - Cell and tissue …, 2013 - Springer
Recent studies have revealed that long non-coding RNAs (lncRNAs) play important roles in
cancer biology and that lncRNA gas5 (growth arrest-specific 5) regulates breast cancer cell …

Development of potent dimeric inhibitors of GAS41 YEATS domain

D Listunov, BM Linhares, EG Kim, A Winkler… - Cell chemical …, 2021 - cell.com
GAS41 is an emerging oncogene overexpressed and implicated in multiple cancers,
including non-small cell lung cancer (NSCLC). GAS41 is a dimeric protein that contains the …

Gas6 induces cancer cell migration and epithelial–mesenchymal transition through upregulation of MAPK and Slug

Y Lee, M Lee, S Kim - Biochemical and biophysical research …, 2013 - Elsevier
Binding of Gas6 to Axl (Gas6/Axl axis) alters cellular functions, including migration, invasion,
proliferation, and survival. However, the molecular mechanisms underlying Gas6-mediated …

GAS5 inhibits gastric cancer cell proliferation partly by modulating CDK6

X Guo, K Deng, H Wang, J Xia, T Shan… - Oncology research and …, 2015 - karger.com
Introduction: As it is not clear whether growth arrest-specific 5 (GAS5) inhibits gastric cancer
(GC) cell proliferation by regulating cell cycle, we analyzed the effect of GAS5 on cell cycle …

Blockade of stromal Gas6 alters cancer cell plasticity, activates NK cells, and inhibits pancreatic cancer metastasis

L Ireland, T Luckett, MC Schmid, A Mielgo - Frontiers in immunology, 2020 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest cancers due to its
aggressive and metastatic nature. PDA is characterized by a rich tumor stroma with …

LncRNA GAS5 Regulates Gemcitabine Resistance in Pancreatic Carcinoma by Targeting miRNA-21

K Huang, G Yang - Annals of Clinical & Laboratory Science, 2023 - Assoc Clin Scientists
Objective Gemcitabine is the first-line drug for chemotherapy of pancreatic cancer. However,
owing to the inherent and acquired resistance, gemcitabine does not change obviously the …

Overexpression of growth-arrest-specific transcript 5 improved cisplatin sensitivity in hepatocellular carcinoma through sponging miR-222

P Zhao, X Cui, L Zhao, L Liu, D Wang - DNA and Cell Biology, 2020 - liebertpub.com
Long noncoding RNA growth-arrest-specific transcript 5 (GAS5) has been proved to play a
crucial role in cancer chemoresistance. However, the function of GAS5 and its underlying …

Overexpression of GAS6 promotes cell proliferation and invasion in bladder cancer by activation of the PI3K/AKT pathway

S Mao, Y Wu, R Wang, Y Guo, D Bi, W Ma… - OncoTargets and …, 2020 - Taylor & Francis
Background Growth arrest-specific 6 (GAS6) is a secreted vitamin K-dependent protein
abnormally expressed in various human tumor tissues and can activate the receptor Tyro3 …