Overexpression of GAS6 promotes cell proliferation and invasion in bladder cancer by activation of the PI3K/AKT pathway

S Mao, Y Wu, R Wang, Y Guo, D Bi, W Ma… - OncoTargets and …, 2020 - Taylor & Francis
Background Growth arrest-specific 6 (GAS6) is a secreted vitamin K-dependent protein
abnormally expressed in various human tumor tissues and can activate the receptor Tyro3 …

Gas5 exerts tumor-suppressive functions in human glioma cells by targeting miR-222

X Zhao, P Wang, J Liu, J Zheng, Y Liu, J Chen, Y Xue - Molecular Therapy, 2015 - cell.com
Aberrant expression of noncoding RNAs in glioma cells, including long noncoding RNAs
(lncRNAs) and microRNAs, may participate in the progression of glioma. Encoded by …

[HTML][HTML] Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer

RC Tseng, JW Chang, JS Mao, CD Tsai, PC Wu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract Growth-arrest-specific 7 (GAS7) belongs to a group of adaptor proteins that
coordinate the actin cytoskeleton. Among human GAS7 isoforms, only GAS7C possesses a …

[HTML][HTML] GAS6-AS1 overexpression increases GIMAP6 expression and inhibits lung adenocarcinoma progression by sponging miR-24-3p

Y Wang, M Ma, C Li, Y Yang, M Wang - Frontiers in Oncology, 2021 - frontiersin.org
GAS6 antisense RNA 1 (GAS6-AS1) is a long non-coding RNA involved in hepatocellular
carcinoma and gastric cancer. However, the functional role of GAS6-AS1 in lung …

GAS5 knockdown reduces the chemo-sensitivity of non-small cell lung cancer (NSCLC) cell to cisplatin (DDP) through regulating miR-21/PTEN axis

L Cao, J Chen, B Ou, C Liu, Y Zou - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Non-small cell lung cancer (NSCLC), known as the most common type of lung cancer, has
caused great economic losses and brought the patients with NSCLC great suffering. The …

GAS5 is downregulated in gastric cancer cells by promoter hypermethylation and regulates adriamycin sensitivity.

N Zhang, AY Wang, XK Wang… - European Review for …, 2016 - search.ebscohost.com
OBJECTIVE: GAS5 is a tumor suppressive lncRNA that is downregulated in gastric cancer.
In this study, we firstly investigated whether epigenetic regulation contributed to GAS5 …

The GAS5/miR-222 axis regulates proliferation of gastric cancer cells through the PTEN/Akt/mTOR pathway

Y Li, J Gu, H Lu - Digestive diseases and sciences, 2017 - Springer
Background Several lines of evidence have indicated that growth arrest-specific transcript 5
(GAS5) functions as a tumor suppressor and is aberrantly expressed in multiple cancers …

[PDF][PDF] GAS5 modulated autophagy is a mechanism modulating cisplatin sensitivity in NSCLC cells.

N Zhang, GQ Yang, XM Shao… - European Review for …, 2016 - europeanreview.org
OBJECTIVE: In this study, we investigated the association between lncRNA GAS5 and
cisplatin (DDP) resistance in NSCLC and further studied the regulative effect of GAS5 on …

Targeting Gas6/TAM in cancer cells and tumor microenvironment

G Wu, Z Ma, Y Cheng, W Hu, C Deng, S Jiang, T Li… - Molecular cancer, 2018 - Springer
Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein,
which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a …

GAS5‑mediated regulation of cell signaling

Y Zhou, B Chen - Molecular medicine reports, 2020 - spandidos-publications.com
In recent years, an increasing number of long non‑coding RNAs (lncRNAs) have been
discovered using microarrays and nucleic acid sequencing technology. LncRNAs exert …