Hepatocellular carcinoma (HCC) is a devastating malignancy without targeted therapeutic
options. Our results indicated that the histone demethylase GASC1 signature is associated …

Repurposing “old” drugs can facilitate rapid clinical translation but necessitates novel
mechanistic insight. Warfarin, a vitamin K “antagonist” used clinically for the prevention of …

Objective The long non-coding RNA Growth-arrest-specific transcript 5 (GAS5) has been
extensively linked with the ability of cancer cells to resist chemotherapeutic interventions …

Long noncoding RNA (lncRNA) plays pivotal roles in cancer development. To date, only a
small number of lncRNAs have been characterized at functional level. Here, we discovered …

The growth arrest-specific gene 7 (GAS7), a member of the growth-arrest-specific family,
encodes three protein isoforms (GAS7A, GAS7B, and GAS7C) and plays a potential role in …

The acquisition of drug resistance is a major hurdle for effective cancer treatment. Although
several efforts have been made to overcome drug resistance, the underlying mechanisms …

Since growth arrest-specific gene 6 (Gas6) was discovered in 1988, numerous studies have
highlighted the role of the Gas6 protein and its receptors Tyro3, Axl and Mer (collectively …

Objective To explore the core mechanism of long non-coding RNA (lncRNA) growth arrest-
specific transcript 5 (GAS5) in the regulation of multidrug resistance of pancreatic cancer …

Hepatocellular carcinoma (HCC) is one of the most common fatal cancers worldwide. Other
than the sorafenib treatment, no effective systemic therapy has been available thus far. Most …

Objective: Chemotherapeutic drug resistance is the main obstacle that affects the efficacy of
current therapies of hepatocellular carcinoma (HCC), which needs to be addressed urgently …