OBJECTIVE Genome-wide association studies and linkage studies have identified 20
validated genetic variants associated with obesity and/or related phenotypes. The variants …

Obesity is a major public health problem with a significant genetic component. Multiple DNA
polymorphisms/genes have been shown to be strongly associated with obesity, typically in …

The search for human obesity genes began several decades ago, but efforts have
intensified in recent years with the completion of the Human Genome Project and advances …

OBJECTIVE Large-scale genome-wide association (GWA) studies have thus far identified
16 loci incontrovertibly associated with obesity-related traits in adults. We examined …

The genetic architecture of obesity is still a matter of debate. The previously accepted
hypothesis of a small number of common variants has been undermined by the low …

Obesity is a major public health problem with strong genetic determination. Multiple genetic
variants have been implicated for obesity by conducting genome-wide association (GWA) …

Despite a relatively high heritability, the search for obesity-susceptibility genes has been
challenging. While over the past 15 years, candidate gene studies and genome-wide …

Before the advent of genome-wide association studies (GWASs), hundreds of candidate
genes for obesity-susceptibility had been identified through a variety of approaches. We …

Obesity is a disorder characterized by an excess accumulation of body fat resulting from a
mismatch between energy intake and expenditure. Incidence of obesity has increased …

Tremendous progress has been made in the genetic elucidation of obesity over the past two
decades, driven largely by technological, methodological and organizational innovations …