Objectives: Investigation of the mode of action of the naphthoimidazole N1, obtained from
the reaction of β-lapachone with benzaldehyde, which among 45 semi-synthetic derivatives …

Three naphthoimidazoles presenting aromatic groups attached to the imidazole ring were
the most active against trypomastigotes of Trypanosoma cruzi between 45 derivatives from β …

In a screening of 65 derivatives of natural quinones using bloodstream trypomastigotes of
Trypanosoma cruzi, the 3 naphthoimidazoles derived from β-lapachone–N1, N2 and N3 …

The available chemotherapy for Chagas disease, caused by Trypanosoma cruzi, is
unsatisfactory; therefore, there is an intense effort to find new drugs for the treatment of this …

Derivatives of natural quinones with biological activities, such as lapachol, α-and β-
lapachones, have been synthesized and their trypanocidal activity evaluated in vitro in …

Abstract Background Naphthoquinones (NQs) are privileged structures in medicinal
chemistry due to the biological effects associated with the induction of oxidative stress. The …

New naphthoquinone derivatives were synthesized and assayed against bloodstream
trypomastigote forms of Trypanosoma cruzi, the etiological agent of Chagas' disease. The …

Chagas disease is caused by the hemoflagellate protozoa Trypanosoma cruzi and is one of
the most important neglected tropical diseases, especially in Latin American countries …

Addition of β-lapachone, an o-naphthoquinone with bactericidal, cytotoxic, and trypanocidal
activities, to Trypanosoma cruzi epimastigote and amastigote stages induced the release of …

Background Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi
that affects millions of people, mainly in Latin America where it is considered endemic. The …