Malignant glioma is the most common brain tumor in adults and is associated with a very
poor prognosis. Mutations in the p53 tumor suppressor gene are frequently detected in …

There is increasing evidence that tumors are heterogeneous and that a subset of cells act as
cancer stem cells. Several proto-oncogenes and tumor suppressors control key aspects of …

Gliomas have been classified according to their histological properties. However, their
respective cells of origin are still unknown. Neural progenitor cells (NPC) from the …

The p53 tumor suppressor potently limits the growth of immature and mature neurons under
conditions of cellular stress. Although loss of p53 function contributes to the pathogenesis of …

p53 is one of the most intensively studied tumor suppressors. It transcriptionally regulates a
broad range of genes to modulate a series of cellular events, including DNA damage repair …

Survival rates for metastatic neuroblastoma remain poor, despite significant increase in the
intensity of therapy. Although it represents approximately 7% of pediatric cancer …

The tumor suppressor and transcription factor p53 plays critical roles in tumor prevention by
orchestrating a wide variety of cellular responses, including damaged cell apoptosis …

Emerging evidence suggests that p53, a tumor suppressor protein primarily involved in
cancer biology, coordinates a wide range of novel functions in the CNS including the …

Recent studies have identified genes and core pathways that are altered in human
glioblastoma. However, the mechanisms by which alterations of these glioblastoma genes …

Simple Summary Current standard care for high-grade glioma involves maximal safe
resection followed by chemoradiation. Recent studies showed that surviving cancer cells …