High grade gliomas, the most frequent and most malignant brain cancers, grow rapidly and
infiltrate the cerebrospinal axis causing deficits in cognition, mobility, balance or speech and …

It has been suggested that intrinsic brain tumours originate from a neural stem/progenitor
cell population in the subventricular zone of the post‐natal brain. However, the influence of …

As the guardian of the genome, the tumor suppressor p53 prevents the accumulation of
genetic mutations by inducing cell cycle arrest, apoptosis or senescence of somatic cells …

The adult mammalian brain contains neural stem cells that are capable of generating new
neurons and glia over the course of a lifetime. Neural stem cells reside in 2 germinal niches …

This article reviews the recent molecular and clinical studies that characterize the role of p53
in pathologies of the central nervous system, p53 has many important biological functions …

This review presents compelling evidence that human glioblastoma is a heterogenous tumor
composed from tumor cells and small portion of cancer stem cells–tumor-initiating cells …

Mutations in the tumor suppressor p53 are the most frequent alterations in human cancer.
These mutations include p53-inactivating mutations as well as oncogenic gain-of-function …

Significance: The p53 family of transcription factors, including p53, p63, and p73, plays key
roles in both biological and pathological processes, including cancer and neural …

Glioblastoma multiforme (GBM) develops from astrocytes and is the most aggressive primary
cancer in humans. Invading cells grow rapidly and form their own blood vessels making …

The cancer stem cell (CSC) hypothesis is predicated on the idea that not all cells have equal
proliferative potential and that, in brain tumors, the cells with the greatest ability to proliferate …