The islets of Langerhans are highly organized structures that have species-specific, three-
dimensional tissue architecture. Islet architecture is critical for proper hormone secretion in …

The islets of Langerhans are dynamic structures that can change in size, number of cells,
and molecular function in response to physiological and pathological stress. Molecular cues …

The pancreatic islets of Langerhans regulate glucose homeostasis. The loss of insulin-
producing β cells within islets results in diabetes, and islet transplantation from cadaveric …

Morphogenesis, spontaneous formation of organism structure, is essential for life. In the
pancreas, endocrine,, and cells are clustered to form islets of Langerhans, the critical micro …

Pancreatic islets are highly vascularized mini-organs that include endocrine cells,
endothelial cells, and extracellular matrix. The three-dimensional islet structure and …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Progress in diabetes research is hindered, in part, by deficiencies in current experimental
systems to accurately model human pathophysiology and/or predict clinical outcomes …

Human islets exhibit distinct islet architecture particularly in large islets that comprise of a
relatively abundant fraction of α-cells intermingled with β-cells, whereas mouse islets show …

The islets of Langerhans, micro-organs for maintaining glucose homeostasis, range in size
from small clusters of< 10 cells to large islets consisting of several thousand endocrine cells …

Studies on diabetes have long been hampered by a lack of authentic disease models that,
ideally, should be unlimited and able to recapitulate the abnormalities involved in the …