A common pathological hallmark among different neurodegenerative diseases is the
accumulation of aggregated proteins that might cause cellular dysfunction and, eventually …

Cellular deposition of protein aggregates, one of the hallmarks of neurodegeneration,
disrupts cellular functions and leads to neuronal death. Mutations, posttranslational …

A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

Several neurodegenerative diseases are characterized by the accumulation of aggregated
misfolded proteins. These pathological agents have been suggested to propagate in the …

Neurodegenerative diseases are estimated by the World Health Organization to be the
second leading cause of human death by 2050. They actually are a group of chronic …

Protein misfolding is the hallmark of a large number of neurodegenerative diseases and is
characterized by the presence of amyloid inclusions composed of aggregates of misfolded …

Progressive accumulation of specific protein aggregates is a defining feature of many major
neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, fronto …

Specific protein misfolding and aggregation are mechanisms underlying various
neurodegenerative diseases such as prion disease and Alzheimer's disease (AD). The …

Protein misfolding is common to most neurodegenerative diseases, including Alzheimer's
and Parkinson's diseases. Recent work using animal models with intracellular α-synuclein …

The misfolding and aggregation of specific proteins is a common hallmark of many
neurodegenerative disorders, including highly prevalent illnesses such as Alzheimer's and …