TadA-derived cytosine base editors (TadCBEs) enable programmable C• G-to-T• A editing
while retaining the small size, high on-target activity, and low off-target activity of TadA …

Base editors (BEs) are a recent generation of genome editing tools that couple a cytidine or
adenosine deaminase activity to a catalytically impaired Cas9 moiety (nCas9) to enable …

Base editors are genome editing tools that enable site‐specific base conversions through
the chemical modification of nucleobases in DNA. Adenine base editors (ABEs) convert A⋅ …

Adenine base editors (ABEs) catalyze specific A-to-G conversions at genomic sites of
interest. However, ABEs also induce cytosine deamination at the target site. To reduce the …

Both adenine base editors (ABEs) and cytosine base editors (CBEs) have been recently
revealed to induce transcriptome-wide RNA off-target editing in a guide RNA-independent …

Cytosine base editors (CBEs) and adenine base editors (ABEs) enable precise C-to-T and A-
to-G edits. Recently, ABE8e, derived from TadA-8e, enhances A-to-G edits in mammalian …

The newly developed CRISPR/Cas9-mediated base editing technology with cytosine
deaminase is capable of precisely and efficiently introducing point mutations at the target …

Dear Editor, Adenine base editor (ABE) enables single-nucleotide conversions from A to G
efficiently without doublestranded DNA breaks. ABE is a powerful tool for targeted base …

Cytosine base editors (CBEs), which enable precise C-to-T substitutions, have been
restricted by potential safety risks, including DNA off-target edits, RNA off-target edits and …

Genome editing is a revolutionary technology that holds immense promise for creating
livestock or crops with improved traits and curing incurable inherited diseases by correcting …