Cytosine base editing enables the installation of specific point mutations without double-
strand breaks in DNA and is advantageous for various applications such as gene therapy …

Base editors (BEs) are genome editing agents that install point mutations with high efficiency
and specificity. Due to their reliance on uracil and inosine DNA damage intermediates …

The fusion of CRISPR–Cas9 with cytidine deaminases leads to base editors (BEs) capable
of programmable C-to-T editing, which has potential in clinical applications but suffers from …

CRISPR/Cas-derived base editing tools empower efficient alteration of genomic cytosines or
adenines associated with essential genetic traits in plants and animals. Diversified target …

Background Many favorable traits of crops and livestock and human genetic diseases arise
from multiple single nucleotide polymorphisms or multiple point mutations with …

Base editor (BE) is a gene-editing tool developed by combining the CRISPR/Cas system
with an individual deaminase, enabling precise single-base substitution in DNA or RNA …

The adenine base editor (ABE), capable of catalyzing A• T to G• C conversions, is an
important gene editing toolbox. Here, we systematically evaluate genome-wide off-target …

Base editors (BEs) have been recently developed by combining the APOBEC
(apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like)/AID (activation-induced …

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9)-mediated genome editing can efficiently produce gene-knockout mutants …

Base editing requires that the target sequence satisfy the protospacer adjacent motif
requirement of the Cas9 domain and that the target nucleotide be located within the editing …