Chimerism testing after allogeneic stem cell transplantation: importance of timing and optimal technique for testing in different clinical–biological situations

T Lion - Leukemia, 2001 - nature.com
The monitoring of chimerism has become a routine diagnostic instrument at centers
performing allogeneic stem cell or bone marrow transplantation. Despite the widespread …

Diagnostic value of highly-sensitive chimerism analysis after allogeneic stem cell transplantation

L Sellmann, K Rabe, I Bünting, E Dammann… - Bone marrow …, 2018 - nature.com
Conventional analysis of host chimerism (HC) frequently fails to detect relapse before its
clinical manifestation in patients with hematological malignancies after allogeneic stem cell …

Minimal residual disease diagnostics and chimerism in the post‐transplant period in acute myeloid leukemia

U Bacher, T Haferlach, B Fehse… - The Scientific World …, 2011 - Wiley Online Library
In acute myeloid leukemia (AML), the selection of poor‐risk patients for allogeneic
hematopoietic stem cell transplantation (HSCT) is associated with rather high post …

Sequential molecular monitoring of chimerism in chronic myeloid leukemia patients receiving donor lymphocyte transfusion for relapse after bone marrow …

MC Rapanotti, W Arcese, S Buffolino, AP Iori… - Bone marrow …, 1997 - nature.com
Recent observations of chimerism in patients relapsed following an allotransplant suggest
the persistence of immunotolerance, thus offering a biologic rationale for the use of donor …

[HTML][HTML] Early achievement of full donor chimerism after allogeneic hematopoietic stem cell transplantation predicts lower relapse risk in patients with acute …

CT Chen, JP Gau, JH Liu, TJ Chiou, LT Hsiao… - Journal of the Chinese …, 2018 - Elsevier
Background Acute lymphoblastic leukemia (ALL) remains one of the most difficult-to-cure
hematological malignancies. Allogeneic hematopoietic stem cell transplantation (HSCT) …

[HTML][HTML] Prognostic utility of routine chimerism testing at 2 to 6 months after allogeneic hematopoietic cell transplantation

GI Mossallam, AM Kamel, B Storer, PJ Martin - Biology of Blood and …, 2009 - Elsevier
The utility of routine chimerism analysis as a prognostic indicator of subsequent outcomes
after allogeneic hematopoietic cell transplantation (HCT) with myeloablative conditioning …

Quantitative analysis of chimerism after allogeneic stem cell transplantation by real‐time polymerase chain reaction with single nucleotide polymorphisms, standard …

M Koldehoff, NK Steckel, M Hlinka… - American journal of …, 2006 - Wiley Online Library
We compared the results of chimerism analyses with real‐time SNP‐PCR to those obtained
by the classical STR‐PCR method in 135 hematopoietic stem cell transplantation recipients …

Impact of chimaerism analysis and kinetics on allogeneic haematopoietic stem cell transplantation outcome after conventional and reduced‐intensity conditioning …

AS Michallet, S Fürst, QH Le, V Dubois… - British journal of …, 2005 - Wiley Online Library
This retrospective study aimed to analyse the impact on overall survival (OS) and event‐free
survival (EFS) of chimaerism status and kinetics following allogeneic conventional and …

Incidence of mixed chimaerism and clinical outcome in 101 patients after myeloablative conditioning regimens and allogeneic stem cell transplantation

R Wäsch, H Bertz, R Kunzmann… - British journal of …, 2000 - Wiley Online Library
In the light of reduced intensity conditioning regimens for allogeneic transplantation,
monitoring of donor cell engraftment acquires new relevance. We analysed the clinical …

How and when should we monitor chimerism after allogeneic stem cell transplantation?

P Bader, D Niethammer, A Willasch… - Bone marrow …, 2005 - nature.com
Chimerism analysis has become an important tool for the peri-transplant surveillance of
engraftment. It offers the possibility to realize impending graft rejection and can serve as an …