Sigma receptor knockdown augments dysfunction and apoptosis of beta cells induced by palmitate
M Ke, G He, H Wang, S Cheng… - Experimental Biology and …, 2021 - journals.sagepub.com
Sigma-1 receptor (Sig-1R) is located in the endoplasmic reticulum (ER) and clustered on the
mitochondria related endoplasmic membranes, which are involved in the regulation of …
mitochondria related endoplasmic membranes, which are involved in the regulation of …
[HTML][HTML] Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells
M Ke, F Lin, H Wang, G He, J Feng… - Molecular …, 2022 - spandidos-publications.com
Abstract Sigma‑1 receptor (Sig‑1R) is a class of orphan receptors, the potential role of which
in pancreatic islet cells remains poorly understood. The present study aimed to investigate …
in pancreatic islet cells remains poorly understood. The present study aimed to investigate …
Knocking out sigma-1 receptors reveals diverse health problems
S Couly, N Goguadze, Y Yasui, Y Kimura… - Cellular and molecular …, 2020 - Springer
Abstract Sigma-1 receptor (Sig-1R) is a protein present in several organs such as brain,
lung, and heart. In a cell, Sig-1R is mainly located across the membranes of the …
lung, and heart. In a cell, Sig-1R is mainly located across the membranes of the …
Sigma-1 receptor as a protective factor for diabetes-associated cognitive dysfunction via regulating astrocytic endoplasmic reticulum-mitochondrion contact and …
M Du, T Jiang, S He, B Cheng, X Zhang, L Li, L Yang… - Cells, 2023 - mdpi.com
The prevalence of diabetes-associated cognitive dysfunction (DACD) has increased to
13.5%. Dementia, as the most severe DACD, is the second leading cause of death in …
13.5%. Dementia, as the most severe DACD, is the second leading cause of death in …
Silibinin protects β cells from glucotoxicity through regulation of the Insig-1/SREBP-1c pathway
K Chen, L Zhao, H He, X Wan… - … journal of molecular …, 2014 - spandidos-publications.com
Exposure to high glucose may cause glucotoxicity, leading to pancreatic β cell dysfunction
including cell apoptosis, impaired glucose‑stimulated insulin secretion (GSIS) and …
including cell apoptosis, impaired glucose‑stimulated insulin secretion (GSIS) and …
Loss of Sigma‐1 Receptor Chaperone Promotes Astrocytosis and Enhances the Nrf2 Antioxidant Defense
TY Weng, DT Hung, TP Su… - Oxidative medicine and …, 2017 - Wiley Online Library
Sigma‐1 receptor (Sig‐1R) functions as a chaperon that interacts with multiple proteins and
lipids and is implicated in neurodegenerative and psychiatric diseases. Here, we used Sig …
lipids and is implicated in neurodegenerative and psychiatric diseases. Here, we used Sig …
Rosiglitazone counteracts palmitate-induced β-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities
SM Abaraviciene, I Lundquist, A Salehi - Cellular and Molecular Life …, 2008 - Springer
Chronic exposure of pancreatic islets to elevated levels of palmitate leads to β-cell
dysfunction. We examined possible involvement of mitogenactivated protein kinases …
dysfunction. We examined possible involvement of mitogenactivated protein kinases …
Sigma-1 receptor ablation impedes adipocyte-like differentiation of mouse embryonic fibroblasts
Abstract The sigma-1 receptor (Sig1R) is a unique ligand-operated endoplasmic reticulum
(ER) protein without any mammalian homolog. It has long been a pharmacological target for …
(ER) protein without any mammalian homolog. It has long been a pharmacological target for …
Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha
Y Sun, J Yang, W Liu, G Yao, F Xu, T Hayashi… - Molecular and Cellular …, 2019 - Springer
High levels of circulating free fatty acids often trigger pancreatic β cell dysfunction during the
development of type 2 diabetes. Silibinin, the main component of Silybum marianum fruit …
development of type 2 diabetes. Silibinin, the main component of Silybum marianum fruit …
SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and …
T Tuerxun, T Numakawa, N Adachi, E Kumamaru… - Neuroscience …, 2010 - Elsevier
Many studies suggest that antidepressants act as neuroprotective agents in the central
nervous system (CNS), though the underlying mechanism has not been fully elucidated. In …
nervous system (CNS), though the underlying mechanism has not been fully elucidated. In …