Sigma-1 receptor (Sig-1R) is located in the endoplasmic reticulum (ER) and clustered on the
mitochondria related endoplasmic membranes, which are involved in the regulation of …

Abstract Sigma‑1 receptor (Sig‑1R) is a class of orphan receptors, the potential role of which
in pancreatic islet cells remains poorly understood. The present study aimed to investigate …

Abstract Sigma-1 receptor (Sig-1R) is a protein present in several organs such as brain,
lung, and heart. In a cell, Sig-1R is mainly located across the membranes of the …

The prevalence of diabetes-associated cognitive dysfunction (DACD) has increased to
13.5%. Dementia, as the most severe DACD, is the second leading cause of death in …

Exposure to high glucose may cause glucotoxicity, leading to pancreatic β cell dysfunction
including cell apoptosis, impaired glucose‑stimulated insulin secretion (GSIS) and …

Sigma‐1 receptor (Sig‐1R) functions as a chaperon that interacts with multiple proteins and
lipids and is implicated in neurodegenerative and psychiatric diseases. Here, we used Sig …

Chronic exposure of pancreatic islets to elevated levels of palmitate leads to β-cell
dysfunction. We examined possible involvement of mitogenactivated protein kinases …

Abstract The sigma-1 receptor (Sig1R) is a unique ligand-operated endoplasmic reticulum
(ER) protein without any mammalian homolog. It has long been a pharmacological target for …

High levels of circulating free fatty acids often trigger pancreatic β cell dysfunction during the
development of type 2 diabetes. Silibinin, the main component of Silybum marianum fruit …

Many studies suggest that antidepressants act as neuroprotective agents in the central
nervous system (CNS), though the underlying mechanism has not been fully elucidated. In …