Chalcones: an update on cytotoxic and chemoprotective properties

ML Go, X Wu, XL Liu - Current medicinal chemistry, 2005 - ingentaconnect.com
Chalcone is a unique template that is associated with several biological activities. In this
review, an update of the cytotoxic and chemoprotective activities of chalcones is provided …

Recent advances in therapeutic chalcones

L Ni, CQ Meng, JA Sikorski - Expert Opinion on Therapeutic Patents, 2004 - Taylor & Francis
Naturally-occurring and synthetic chalcone compounds have shown promising biological
activity and safety profiles and have the potential to be developed as, or more properly …

Chalcone derivatives: role in anticancer therapy

Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence

B Salehi, C Quispe, I Chamkhi, N El Omari… - Frontiers in …, 2021 - frontiersin.org
Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …

Trends in utilization of the pharmacological potential of chalcones

DI Batovska, IT Todorova - Current clinical pharmacology, 2010 - ingentaconnect.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are open chain flavonoids that are widely
biosynthesized in plants. They are important for the pigmentation of flowers and, hence, act …

Heterocyclic chalcone analogues as potential anticancer agents

V Sharma, V Kumar, P Kumar - Anti-Cancer Agents in Medicinal …, 2013 - ingentaconnect.com
Chalcones, aromatic ketones and enones acting as the precursor for flavonoids such as
Quercetin, are known for their anticancer effects. Although, parent chalcones consist of two …

Chalcones derivatives acting as cell cycle blockers: potential anti cancer drugs?

A Boumendjel, X Ronot, J Boutonnat - Current drug targets, 2009 - ingentaconnect.com
Chalcones (1, 3-diphenylpropen-1-ones) are naturally occurring compounds belonging to
the flavonoid family and are largely investigated in various therapeutic area and especially …

Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer

AA WalyEldeen, S Sabet, HM El-Shorbagy… - Chemico-Biological …, 2023 - Elsevier
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

In vitro evaluation of newly developed chalcone analogues in human cancer cells

R De Vincenzo, C Ferlini, M Distefano… - Cancer chemotherapy …, 2000 - Springer
Purpose: Among flavonoids, chalcones have been identified as interesting compounds
having chemopreventive and antitumor properties. We studied a panel of newly developed …

Chalcones as promising lead compounds on cancer therapy

AJ Leon-Gonzalez, N Acero… - Current medicinal …, 2015 - ingentaconnect.com
Chalcones constitute a group of phenolic compounds that command an increasing interest
on cancer research. Natural chalcones are widespread through the plant kingdom. The most …