Cardiovascular disease (CVD) is the one of major global health issues with approximately
30% of the mortality reported in the mid-income population. Low-density lipoprotein (LDL) …

Cholesterol is a structural component of the plasma membrane that surrounds animal cells.
It is absolutely essential for cell growth and survival. Yet, excessive amounts of cholesterol …

Low-density lipoproteins (LDLs, also known as 'bad cholesterol') are the major carriers of
circulating cholesterol and the main causative risk factor of atherosclerosis. Plasma LDLs …

Alterations in plasma lipoproteins are major risk factors for coronary heart disease caused
by atherosclerosis. The purpose of this chapter is to provide the reader with an overview of …

The endogenous lipoprotein system (very low-density lipoprotein [VLDL], intermediate-
density lipoprotein [IDL], low-density lipoprotein [LDL] cascade) holds the key to …

Human low-density lipoprotein (LDL) is a spherical particle with a diameter of 220 Å and a
molecular weight of about 2.5 million. LDL consists of an interior core of esterified …

In man and in experimental animals, elevations in plasma cholesterol lead to premature
atherosclerosis. It is likely that the cholesterol-rich low density lipoprotein (LDL) plays a …

Binding of homologous low density lipoproteins (LDL) to specific cell‐membrane receptors
initiates regulation of cholesterol metabolism in normal human fibroblasts, but minor …

Traditional risk factors for coronary artery disease (CAD) predict about 50% of the risk of
developing CAD. The Adult Treatment Panel (ATP) III has defined emerging risk factors for …

Despite significant progress in the management of atherosclerosis and its resultant
complications, cardiovascular disease remains the principal cause of death in the world. The …