Vaccines against tuberculosis: where are we and where do we need to go?
THM Ottenhoff, SHE Kaufmann - PLoS pathogens, 2012 - journals.plos.org
In this review we discuss recent progress in the development, testing, and clinical evaluation
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …
Tuberculosis vaccine development: progress in clinical evaluation
Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite
extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer …
extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer …
Novel vaccination strategies against tuberculosis
P Andersen, SHE Kaufmann - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
The tuberculosis (TB) pandemic continues to rampage despite widespread use of the BCG
(Bacillus Calmette–Guérin) vaccine. Novel vaccination strategies are urgently needed to …
(Bacillus Calmette–Guérin) vaccine. Novel vaccination strategies are urgently needed to …
[HTML][HTML] Tuberculosis vaccines–state of the art, and novel approaches to vaccine development
C da Costa, B Walker, A Bonavia - International Journal of Infectious …, 2015 - Elsevier
The quest for a vaccine that could have a major impact in reducing the current global burden
of TB disease in humans continues to be extremely challenging. Significant gaps in our …
of TB disease in humans continues to be extremely challenging. Significant gaps in our …
An overview of the development of new vaccines for tuberculosis
E Whitlow, AS Mustafa, SNM Hanif - Vaccines, 2020 - mdpi.com
Currently, there is only one licensed vaccine against tuberculosis (TB), the Bacillus Calmette–
Guérin (BCG). Despite its protective efficacy against TB in children, BCG has failed to protect …
Guérin (BCG). Despite its protective efficacy against TB in children, BCG has failed to protect …
[HTML][HTML] Vaccine development against tuberculosis over the last 140 years: Failure as part of success
SHE Kaufmann - Frontiers in Microbiology, 2021 - frontiersin.org
The year 2020 was shaped by the COVID-19 pandemic which killed more people than any
other infectious disease in this particular year. At the same time, the development of highly …
other infectious disease in this particular year. At the same time, the development of highly …
[PDF][PDF] What's new in tuberculosis vaccines?
AM Ginsberg - Bulletin of the World Health Organization, 2002 - SciELO Public Health
Over the past 10 years, tuberculosis (TB) vaccine development has resurged as an active
area of investigation. The renewed interest has been stimulated by the recognition that …
area of investigation. The renewed interest has been stimulated by the recognition that …
Novel tuberculosis vaccines on the horizon
SK Parida, SHE Kaufmann - Current opinion in immunology, 2010 - Elsevier
Eleven new tuberculosis (TB) vaccines are in various phases of clinical trials. These include
subunit vaccines to improve the current vaccine BCG, and recombinant BCG to substitute for …
subunit vaccines to improve the current vaccine BCG, and recombinant BCG to substitute for …
Moving tuberculosis vaccines from theory to practice
P Andersen, TJ Scriba - Nature Reviews Immunology, 2019 - nature.com
Tuberculosis (TB) vaccine research has reached a unique point in time. Breakthrough
findings in both the basic immunology of Mycobacterium tuberculosis infection and the …
findings in both the basic immunology of Mycobacterium tuberculosis infection and the …
[HTML][HTML] Novel approaches to tuberculosis vaccine development
SHE Kaufmann, J Weiner, CF von Reyn - International Journal of Infectious …, 2017 - Elsevier
Tuberculosis (TB) remains the deadliest infectious disease. The widely used bacille
Calmette–Guérin (BCG) vaccine offers only limited protection against TB. New vaccine …
Calmette–Guérin (BCG) vaccine offers only limited protection against TB. New vaccine …